4-Hydroxystrychnidin-10-one

Base Information

• Chemical Name: 4-Hydroxystrychnidin-10-one
• CAS No.: 22595-26-2
• Molecular Formula: C₂₁H₂₂N₂O₃
• Molecular Weight: 350.417
• Mol file: 22595-26-2.mol

Synonyms:Strychnine,4-hydroxy- (8CI);4,6-Methano-6H,14H-indolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinoline,strychnidin-10-one deriv.; 4-Hydroxystrychnine

Chemical Property of 4-Hydroxystrychnidin-10-one

Chemical Property:

• Vapor Pressure: 5.33E-15mmHg at 25°C
• Boiling Point: 600.2°C at 760 mmHg
• Flash Point: 316.8°C
• PSA: 53.01000
• Density: 1.51g/cm³
• LogP: 1.80100

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Hydroxystrychnidin-10-one

There total 2 articles about 4-Hydroxystrychnidin-10-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Aminostrychnin (75327-01-4) → 12-hydroxystrychnine (22595-26-2)

Guidance literature:

With sodium nitrite; Yield given. Multistep reaction; 1) 2N H₂SO₄, 50 deg C, 2) 2N H₂SO₄, 2 h, reflux;

DOI:10.1002/jlac.198019800610

Reference yield:

2-Brom-4-nitrostrychnin (100736-08-1) → 12-hydroxystrychnine (22595-26-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium-amalgan

2: 1) 5percent sodium nitrite / 1) 2N H₂SO₄, 50 deg C, 2) 2N H₂SO₄, 2 h, reflux

With sodium amalgam; sodium nitrite;

DOI:10.1002/jlac.198019800610

Reference yield:

12-hydroxystrychnine (22595-26-2) → strychnicine (125-15-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 850 mg / 15percent H₂O₂ / 80 °C

2: 110 mg / potassium chromate / 70 °C

3: 23 mg / methanol / 96 h / 40 - 45 °C

With methanol; potassium chromate; dihydrogen peroxide;

DOI:10.1002/jlac.198019800610

upstream raw materials:

4-Aminostrychnin

2-Brom-4-nitrostrychnin

Downstream raw materials:

strychnicine

Refernces