(3R,4S)-4-Benzyl-1-(4-methoxy-phenyl)-3-triisopropylsilanyloxy-azetidin-2-one

Base Information

• Chemical Name: (3R,4S)-4-Benzyl-1-(4-methoxy-phenyl)-3-triisopropylsilanyloxy-azetidin-2-one
• CAS No.: 203806-59-1
• Molecular Formula: C₂₆H₃₇NO₃Si
• Molecular Weight: 439.67
• Mol file: 203806-59-1.mol

Synonyms:(3R,4S)-4-Benzyl-1-(4-methoxy-phenyl)-3-triisopropylsilanyloxy-azetidin-2-one

Chemical Property of (3R,4S)-4-Benzyl-1-(4-methoxy-phenyl)-3-triisopropylsilanyloxy-azetidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R,4S)-4-Benzyl-1-(4-methoxy-phenyl)-3-triisopropylsilanyloxy-azetidin-2-one

There total 4 articles about (3R,4S)-4-Benzyl-1-(4-methoxy-phenyl)-3-triisopropylsilanyloxy-azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

Acetic acid [(2S,3R)-1-(4-methoxy-phenyl)-4-oxo-3-triisopropylsilanyloxy-azetidin-2-yl]-phenyl-methyl ester (203806-58-0) → (3R,4S)-4-Benzyl-1-(4-methoxy-phenyl)-3-triisopropylsilanyloxy-azetidin-2-one (203806-59-1)

Guidance literature:

With hydrogen; In ethyl acetate; at 40 ℃; under 5171.5 Torr;

DOI:10.1016/S0040-4039(97)10677-3

Reference yield:

(3R,4S)-1-(4-methoxyphenyl)-3-triisopropylsiloxy-4-(2-methylprop-1-enyl)azetidin-2-one (178250-07-2) → (3R,4S)-4-Benzyl-1-(4-methoxy-phenyl)-3-triisopropylsilanyloxy-azetidin-2-one (203806-59-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) O₃, 2.) Me₂S / 1.) -78 deg C

2: -70 - -40 °C

3: DMAP / Ambient temperature

4: 74 percent / H₂ / ethyl acetate / 40 °C / 5171.5 Torr

With dmap; dimethylsulfide; hydrogen; ozone; In ethyl acetate;

DOI:10.1016/S0040-4039(97)10677-3

Reference yield:

(3R,4R)-1-(4-methoxyphenyl)-3-triisopropylsiloxy-4-formylazetidin-2-one (245657-85-6) → (3R,4S)-4-Benzyl-1-(4-methoxy-phenyl)-3-triisopropylsilanyloxy-azetidin-2-one (203806-59-1)

Guidance literature:

Multi-step reaction with 3 steps

1: -70 - -40 °C

2: DMAP / Ambient temperature

3: 74 percent / H₂ / ethyl acetate / 40 °C / 5171.5 Torr

With dmap; hydrogen; In ethyl acetate;

DOI:10.1016/S0040-4039(97)10677-3

upstream raw materials:

Acetic acid [(2S,3R)-1-(4-methoxy-phenyl)-4-oxo-3-triisopropylsilanyloxy-azetidin-2-yl]-phenyl-methyl ester

(3R,4S)-1-(4-methoxyphenyl)-3-triisopropylsiloxy-4-(2-methylprop-1-enyl)azetidin-2-one

(3R,4R)-1-(4-methoxyphenyl)-3-triisopropylsiloxy-4-formylazetidin-2-one

Downstream raw materials:

(2S,3R)-2-Benzyl-4-oxo-3-triisopropylsilanyloxy-azetidine-1-carboxylic acid tert-butyl ester

(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane

(4S,5S)-2,2-dimethyl-3-(tert-butoxycarbonyl)-4-benzyl-5-formyl-1,3-oxazolidine

(2R,3S)-N-(tert-butoxycarbonyl)-3-amino-2-hydroxy-4-phenylbutanoic acid methyl ester