(4-cyano-phenylamino)-(3,5-diethoxy-2-fluoro-phenyl)-acetic acid ethyl ester

Base Information

Chemical Name:(4-cyano-phenylamino)-(3,5-diethoxy-2-fluoro-phenyl)-acetic acid ethyl ester
CAS No.:277324-22-8
Molecular Formula:C₂₁H₂₃FN₂O₄
Molecular Weight:386.423
Hs Code.:

Synonyms:(4-cyano-phenylamino)-(3,5-diethoxy-2-fluoro-phenyl)-acetic acid ethyl ester

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Chemical Property of (4-cyano-phenylamino)-(3,5-diethoxy-2-fluoro-phenyl)-acetic acid ethyl ester

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Technology Process of (4-cyano-phenylamino)-(3,5-diethoxy-2-fluoro-phenyl)-acetic acid ethyl ester

There total 9 articles about (4-cyano-phenylamino)-(3,5-diethoxy-2-fluoro-phenyl)-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (CH₃CH₂O)2C₆H₂FCHNHC₆H₄CNCHOCH₂CH₃NCHC₆H₅

: 277324-22-8
(4-cyano-phenylamino)-(3,5-diethoxy-2-fluoro-phenyl)-acetic acid ethyl ester

Guidance literature:: With water; In ethanol; at 20 ℃;
DOI:10.1016/j.bmc.2006.03.042

Reference yield:

: (CH₃CH₂O)2C₆H₂FCHNC₆H₄CN

: 277324-22-8
(4-cyano-phenylamino)-(3,5-diethoxy-2-fluoro-phenyl)-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: BF₃*Et₂O / cooling

2: 1.15 g / water / ethanol / 20 °C

With boron trifluoride diethyl etherate; water; In ethanol;
DOI:10.1016/j.bmc.2006.03.042

Reference yield:

: 371-41-5
4-Fluorophenol

: 277324-22-8
(4-cyano-phenylamino)-(3,5-diethoxy-2-fluoro-phenyl)-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 91 percent / imidazole / dimethylformamide / 1 h / 0 °C

2.1: sec-BuLi / tetrahydrofuran; hexane / 0.5 h / -65 °C

2.2: trimethyl borate / tetrahydrofuran; hexane / 1 h / -65 °C

2.3: 73 percent / aq. H₂O₂; acetic acid / 0.5 h / 0 °C

3.1: 99 percent / imidazole / dimethylformamide / 1 h / 0 °C

4.1: sec-BuLi / tetrahydrofuran; hexane / 1 h / -70 °C

4.2: 92 percent / tetrahydrofuran; hexane / 1.5 h / 20 °C

5.1: 55 percent / KF / dimethylformamide / 2 h / 20 °C

6.1: ethanol

7.1: BF₃*Et₂O / cooling

8.1: 1.15 g / water / ethanol / 20 °C

With 1H-imidazole; potassium fluoride; boron trifluoride diethyl etherate; water; sec.-butyllithium; In tetrahydrofuran; ethanol; hexane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.03.042