ethyl 5-(iodomethyl)-2-methyl-1-phenyl-4,5-dihydro-1H-pyrrole-3-carboxylate

Base Information

Chemical Name:ethyl 5-(iodomethyl)-2-methyl-1-phenyl-4,5-dihydro-1H-pyrrole-3-carboxylate
CAS No.:247168-03-2
Molecular Formula:C₁₅H₁₈INO₂
Molecular Weight:371.218
Hs Code.:

Synonyms:ethyl 5-(iodomethyl)-2-methyl-1-phenyl-4,5-dihydro-1H-pyrrole-3-carboxylate

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Chemical Property of ethyl 5-(iodomethyl)-2-methyl-1-phenyl-4,5-dihydro-1H-pyrrole-3-carboxylate

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of ethyl 5-(iodomethyl)-2-methyl-1-phenyl-4,5-dihydro-1H-pyrrole-3-carboxylate

There total 3 articles about ethyl 5-(iodomethyl)-2-methyl-1-phenyl-4,5-dihydro-1H-pyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 247168-00-9
2-[1-Phenylamino-eth-(E)-ylidene]-pent-4-enoic acid ethyl ester

: 247168-03-2
ethyl 5-(iodomethyl)-2-methyl-1-phenyl-4,5-dihydro-1H-pyrrole-3-carboxylate

Guidance literature:: With iodine; sodium hydrogencarbonate; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1055/s-0029-1217053

Reference yield:

: 62-53-3
aniline

: 247168-03-2
ethyl 5-(iodomethyl)-2-methyl-1-phenyl-4,5-dihydro-1H-pyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / Al₂O₃ / 12 h / 70 °C

2: 73 percent / I₂; Al₂O₃; NaHCO₃ / CH₂Cl₂ / 1 h / 20 °C

With aluminum oxide; iodine; sodium hydrogencarbonate; In dichloromethane; 1: Condensation / 2: Cyclization;
DOI:10.1016/S0040-4020(99)00625-0

Reference yield:

: 610-89-9,84984-48-5
2-acetyl-pent-4-enoic acid ethyl ester

: 247168-03-2
ethyl 5-(iodomethyl)-2-methyl-1-phenyl-4,5-dihydro-1H-pyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / Al₂O₃ / 12 h / 70 °C

2: 73 percent / I₂; Al₂O₃; NaHCO₃ / CH₂Cl₂ / 1 h / 20 °C

With aluminum oxide; iodine; sodium hydrogencarbonate; In dichloromethane; 1: Condensation / 2: Cyclization;
DOI:10.1016/S0040-4020(99)00625-0