BQ-123 SODIUM SALT

Base Information

Chemical Name:BQ-123 SODIUM SALT
CAS No.:136553-81-6
Molecular Formula:C31H42 N6 O7
Molecular Weight:610.71
Hs Code.:
Mol file:136553-81-6.mol

Synonyms:1H-Pyrrolo[1,2-a][1,4,7,10,13]pentaazacyclopentadecine,cyclic peptide deriv.; 1: PN: WO2009046880 PAGE: 102 claimed protein; BQ 123

Suppliers and Price of BQ-123 SODIUM SALT

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
BQ-123
500ug
$ 446.00

Usbiological
BQ-123 Sodium Salt
1mg
$ 337.00

TRC
BQ-123
0.1mg
$ 65.00

Tocris
BQ-123
500U
$ 195.00

Sigma-Aldrich
BQ-123 ≥99%, sodium salt, lyophilized powder
200 μg
$ 121.00

Sigma-Aldrich
BQ-123 ≥99%, sodium salt, lyophilized powder
200ug
$ 117.00

Sigma-Aldrich
BQ-123 ≥99%, sodium salt, lyophilized powder
1mg
$ 341.00

DC Chemicals
BQ-123 >98%
1 g
$ 5000.00

CSNpharm
BQ-123
5mg
$ 340.00

CSNpharm
BQ-123
1mg
$ 85.00

Total 59 raw suppliers

Chemical Property of BQ-123 SODIUM SALT

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:978.3°Cat760mmHg
PKA:4.04±0.10(Predicted)
Flash Point:545.5°C
PSA：189.80000
Density:1.282g/cm³
LogP:2.08410
Storage Temp.:−20°C
Solubility.:Soluble to 0.40 mg/ml in sterile

Purity/Quality:

98%,99%, ^*data from raw suppliers

BQ-123 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 22-24/25

MSDS Files:: SDS file from LookChem

Useful:

Uses BQ-123 has been used as a selective endothelin-A receptor antagonist to study its effects on tumor necrosis factor α (TNFα)-induced human airway smooth muscle cells (HASMCs) proliferation. It is also used as endothelin-A receptor antagonist to study its effects on TNFα-induced granulocyte–macrophage colony-stimulating factor (GM-CSF) expression.

Technology Process of BQ-123 SODIUM SALT

There total 4 articles about BQ-123 SODIUM SALT which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 160195-16-4
cyclo-(D-Trp-D-Asp(O-t-Bu)-Pro-D-Val-Leu-)

: 136553-81-6
cyclo(D-Trp-D-Asp-Pro-D-Val-Leu)

Guidance literature:: With ethane-1,2-dithiol; trifluoroacetic acid; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;
DOI:10.1021/jm00021a021

Reference yield:

: 166760-86-7
H-D-Trp-D-Asp(O-t-Bu)-Pro-D-Val-Leu-NHNH₂

: 136553-81-6
cyclo(D-Trp-D-Asp-Pro-D-Val-Leu)

Guidance literature:: Multi-step reaction with 3 steps

1: HCl, isoamyl nitrite / dimethylformamide; dioxane / 0.17 h / -30 °C

2: Et₃N / dimethylformamide / -20 °C / pH 8

3: 68 percent / TFA, 1,2-ethanedithiol / dimethylformamide / 0.25 h / 0 °C

With hydrogenchloride; ethane-1,2-dithiol; triethylamine; trifluoroacetic acid; isopentyl nitrite; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm00021a021

Reference yield:

: (R)-3-[(R)-2-Amino-3-(1H-indol-3-yl)-propionylamino]-4-{(S)-2-[(R)-1-((S)-1-azidocarbonyl-3-methyl-butylcarbamoyl)-2-methyl-propylcarbamoyl]-pyrrolidin-1-yl}-4-oxo-butyric acid tert-butyl ester

: 136553-81-6
cyclo(D-Trp-D-Asp-Pro-D-Val-Leu)

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / dimethylformamide / -20 °C / pH 8

2: 68 percent / TFA, 1,2-ethanedithiol / dimethylformamide / 0.25 h / 0 °C

With ethane-1,2-dithiol; triethylamine; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm00021a021