(2S,3R)-tert-butyl2-((3,3-difluorocyclobutyl)methyl)-6,6,6-trifluoro-3-(((S)-9-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)carbamoyl)hexanoate

Base Information

Chemical Name:(2S,3R)-tert-butyl2-((3,3-difluorocyclobutyl)methyl)-6,6,6-trifluoro-3-(((S)-9-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)carbamoyl)hexanoate
CAS No.:1584139-91-2
Molecular Formula:C₃₂H₃₆F₅N₃O₄
Molecular Weight:621.648
Hs Code.:

(2S,3R)-tert-butyl2-((3,3-difluorocyclobutyl)methyl)-6,6,6-trifluoro-3-(((S)-9-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)carbamoyl)hexanoate

Synonyms:(2S,3R)-tert-butyl2-((3,3-difluorocyclobutyl)methyl)-6,6,6-trifluoro-3-(((S)-9-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)carbamoyl)hexanoate

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Chemical Property of (2S,3R)-tert-butyl2-((3,3-difluorocyclobutyl)methyl)-6,6,6-trifluoro-3-(((S)-9-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)carbamoyl)hexanoate

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Technology Process of (2S,3R)-tert-butyl2-((3,3-difluorocyclobutyl)methyl)-6,6,6-trifluoro-3-(((S)-9-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)carbamoyl)hexanoate

There total 13 articles about (2S,3R)-tert-butyl2-((3,3-difluorocyclobutyl)methyl)-6,6,6-trifluoro-3-(((S)-9-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)carbamoyl)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1581735-11-6
(R)-2-((S)-1-(tert-butoxy)-3-(3,3-difluorocyclobutyl)-1-oxopropan-2-yl)-5,5,5-trifluoropentanoic acid

: (S)-3-amino-9-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one dihydrobromide

: 1584139-91-2
(2S,3R)-tert-butyl2-((3,3-difluorocyclobutyl)methyl)-6,6,6-trifluoro-3-(((S)-9-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)carbamoyl)hexanoate

Guidance literature:: With sodium hydrogencarbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.833333h;

Reference yield:

: (R)-2-((S)-1-(tert-butoxy)-3-(3,3-difluorocyclobutyl)-1-oxopropan-2-yl)-5,5,5-trifluoropentanoic acid

: 1584139-91-2
(2S,3R)-tert-butyl2-((3,3-difluorocyclobutyl)methyl)-6,6,6-trifluoro-3-(((S)-9-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)carbamoyl)hexanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / hexane; tetrahydrofuran; ethylbenzene / 0.83 h / -78 - 20 °C

1.2: 0.42 h / -78 - 20 °C

2.1: sodium hydrogencarbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 0.83 h / 20 °C

With sodium hydrogencarbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; hexane; ethylbenzene; N,N-dimethyl-formamide;

Reference yield:

: 1581734-86-2
2-((3,3-difluorocyclobutyl)methyl)malonic acid

: 1584139-91-2
(2S,3R)-tert-butyl2-((3,3-difluorocyclobutyl)methyl)-6,6,6-trifluoro-3-(((S)-9-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)carbamoyl)hexanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1 h / 160 °C

2.1: borane-THF / hexane; tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

3.1: lithium chloride; lithium diisopropyl amide / hexane; tetrahydrofuran; toluene / 0.5 h / -78 - 0 °C / Inert atmosphere

3.2: 0.25 h / -78 - 40 °C / Inert atmosphere

4.1: water; lithium hydroxide; dihydrogen peroxide / tetrahydrofuran / 0 - 20 °C

5.1: sodium hydrogencarbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 0.83 h / 20 °C

With borane-THF; water; dihydrogen peroxide; sodium hydrogencarbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; lithium chloride; lithium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; toluene;