C₂₃H₂₂F₄N₂O₂

Base Information

Chemical Name:C₂₃H₂₂F₄N₂O₂
CAS No.:686321-45-9
Molecular Formula:C₂₃H₂₂F₄N₂O₂
Molecular Weight:434.433
Hs Code.:

C<sub>23</sub>H<sub>22</sub>F<sub>4</sub>N<sub>2</sub>O<sub>2</sub>

Synonyms:C₂₃H₂₂F₄N₂O₂

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₃H₂₂F₄N₂O₂

Chemical Property:

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Technology Process of C₂₃H₂₂F₄N₂O₂

There total 17 articles about C₂₃H₂₂F₄N₂O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 686321-43-7
C₂₃H₂₄F₂N₂O₃

: 1478-53-1
Diethyl difluoromethylphosphonate

: 686321-45-9
C₂₃H₂₂F₄N₂O₂

Guidance literature:: Diethyl difluoromethylphosphonate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

C₂₃H₂₄F₂N₂O₃; In tetrahydrofuran;

With sodium methylate; In methanol; Further stages.;
DOI:10.1016/j.bmcl.2007.03.006

Reference yield:

: C₂₀H₂₀ClNO₂

: 686321-45-9
C₂₃H₂₂F₄N₂O₂

Guidance literature:: Multi-step reaction with 16 steps

1.1: aq. HCl

2.1: Na₂CO₃ / H₂O

3.1: LAH / tetrahydrofuran / 0 - 20 °C

4.1: TEA / CH₂Cl₂

5.1: O₃ / CH₂Cl₂ / -78 °C

5.2: DMS / CH₂Cl₂

6.1: NaHMDS / tetrahydrofuran / -78 °C

6.2: tetrahydrofuran

7.1: Na₂CO₃; LiCl / Pd(Ph₃P)4 / 1,2-dimethoxy-ethane

8.1: aq. NaOH / ethanol / 60 °C

9.1: imidazole / CH₂Cl₂; dimethylformamide

10.1: TEA / tetrahydrofuran

11.1: HF-TEA / acetonitrile

12.1: 100 percent / Dess-Martin periodinane / CH₂Cl₂

13.1: 67 percent / NaH / tetrahydrofuran

14.1: NiCl₂; NaBH₄ / methanol / 0 °C

15.1: LDA / tetrahydrofuran / -78 °C

15.2: tetrahydrofuran

15.3: 77 percent / NaOMe / methanol

With 1H-imidazole; hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; TEA; sodium hexamethyldisilazane; sodium hydride; sodium carbonate; Dess-Martin periodane; ozone; lithium chloride; nickel dichloride; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 7.1: Suzuki reaction / 14.1: Horner-Wadsworth-Emmons reaction;
DOI:10.1016/j.bmcl.2007.03.006

Reference yield:

: C₁₃H₁₆ClNO₂*HCl

: 686321-45-9
C₂₃H₂₂F₄N₂O₂

Guidance literature:: Multi-step reaction with 15 steps

1.1: Na₂CO₃ / H₂O

2.1: LAH / tetrahydrofuran / 0 - 20 °C

3.1: TEA / CH₂Cl₂

4.1: O₃ / CH₂Cl₂ / -78 °C

4.2: DMS / CH₂Cl₂

5.1: NaHMDS / tetrahydrofuran / -78 °C

5.2: tetrahydrofuran

6.1: Na₂CO₃; LiCl / Pd(Ph₃P)4 / 1,2-dimethoxy-ethane

7.1: aq. NaOH / ethanol / 60 °C

8.1: imidazole / CH₂Cl₂; dimethylformamide

9.1: TEA / tetrahydrofuran

10.1: HF-TEA / acetonitrile

11.1: 100 percent / Dess-Martin periodinane / CH₂Cl₂

12.1: 67 percent / NaH / tetrahydrofuran

13.1: NiCl₂; NaBH₄ / methanol / 0 °C

14.1: LDA / tetrahydrofuran / -78 °C

14.2: tetrahydrofuran

14.3: 77 percent / NaOMe / methanol

With 1H-imidazole; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; TEA; sodium hexamethyldisilazane; sodium hydride; sodium carbonate; Dess-Martin periodane; ozone; lithium chloride; nickel dichloride; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 6.1: Suzuki reaction / 13.1: Horner-Wadsworth-Emmons reaction;
DOI:10.1016/j.bmcl.2007.03.006