5-[(E/Z)-2-(4-fluorophenyl)ethenyl]-6-nitro-1,3-benzodioxole

Base Information

• Chemical Name: 5-[(E/Z)-2-(4-fluorophenyl)ethenyl]-6-nitro-1,3-benzodioxole
• CAS No.: 1204394-28-4
• Molecular Formula: C₁₅H₁₀FNO₄
• Molecular Weight: 287.247
• Mol file: 1204394-28-4.mol

Synonyms:5-[(E/Z)-2-(4-fluorophenyl)ethenyl]-6-nitro-1,3-benzodioxole

Chemical Property of 5-[(E/Z)-2-(4-fluorophenyl)ethenyl]-6-nitro-1,3-benzodioxole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[(E/Z)-2-(4-fluorophenyl)ethenyl]-6-nitro-1,3-benzodioxole

There total 2 articles about 5-[(E/Z)-2-(4-fluorophenyl)ethenyl]-6-nitro-1,3-benzodioxole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-nitro-1,3-benzodioxole-5-carbaldehyde (712-97-0) + (4-fluorobenzyl)(triphenyl)phosphonium bromide (51044-11-2) → 5-[(E/Z)-2-(4-fluorophenyl)ethenyl]-6-nitro-1,3-benzodioxole (1204394-28-4)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; for 4h; Reflux;

DOI:10.1016/j.ejmech.2017.11.057

Reference yield:

4-Fluorobenzyl bromide (459-46-1) → 5-[(E/Z)-2-(4-fluorophenyl)ethenyl]-6-nitro-1,3-benzodioxole (1204394-28-4)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 6 h / 120 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 4 h / Reflux

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; toluene; 2: |Wittig Olefination;

DOI:10.1016/j.ejmech.2017.11.057

Reference yield:

5-[(E/Z)-2-(4-fluorophenyl)ethenyl]-6-nitro-1,3-benzodioxole (1204394-28-4) → C15H10FNO2

Guidance literature:

With bis(N,N-dimethylformamide)dichlorodioxomolybdenum(VI); triphenylphosphine; In toluene; for 16h; Reflux;

DOI:10.1016/j.ejmech.2017.11.057

upstream raw materials:

6-nitro-1,3-benzodioxole-5-carbaldehyde

(4-fluorobenzyl)(triphenyl)phosphonium bromide

4-Fluorobenzyl bromide

Downstream raw materials:

1-(4-fluorophenyl)-2-(6-nitro-1,3-benzodioxol-5-yl)-1,2-ethanedione