1-(2-methyl-1,3-dioxolan-2-yl)-2-nitrobutan-3-one p-toluenesulfonylhydrazone

Base Information

• Chemical Name: 1-(2-methyl-1,3-dioxolan-2-yl)-2-nitrobutan-3-one p-toluenesulfonylhydrazone
• CAS No.: 89329-56-6
• Molecular Formula: C₁₅H₂₁N₃O₆S
• Molecular Weight: 371.414
• Mol file: 89329-56-6.mol

Synonyms:1-(2-methyl-1,3-dioxolan-2-yl)-2-nitrobutan-3-one p-toluenesulfonylhydrazone

Chemical Property of 1-(2-methyl-1,3-dioxolan-2-yl)-2-nitrobutan-3-one p-toluenesulfonylhydrazone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-methyl-1,3-dioxolan-2-yl)-2-nitrobutan-3-one p-toluenesulfonylhydrazone

There total 2 articles about 1-(2-methyl-1,3-dioxolan-2-yl)-2-nitrobutan-3-one p-toluenesulfonylhydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-(2-methyl-1,3-dioxolan-2yl)-2-nitrobutan-3-one (87377-87-5) + toluene-4-sulfonic acid hydrazide (1576-35-8) → 1-(2-methyl-1,3-dioxolan-2-yl)-2-nitrobutan-3-one p-toluenesulfonylhydrazone (89329-56-6)

Guidance literature:

In methanol; for 10h; Ambient temperature;

DOI:10.1016/S0040-4020(01)88632-4

Reference yield:

2-methyl-2-(2-nitroethyl)-1,3-dioxolane (79958-77-3) → 1-(2-methyl-1,3-dioxolan-2-yl)-2-nitrobutan-3-one p-toluenesulfonylhydrazone (89329-56-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Brockmann I alumina, 2.) potassium dichromate, H₂SO₄, tetrabutylammonium hydrogen sulphate / 1.) 24 h, r.t, 2.) CH₂Cl₂, -5 deg C, 3 h.

2: 94 percent / methanol / 10 h / Ambient temperature

With potassium dichromate; aluminum oxide; sulfuric acid; tetra(n-butyl)ammonium hydrogensulfate; In methanol;

DOI:10.1016/S0040-4020(01)88632-4

Reference yield: 80.0%

1-(2-methyl-1,3-dioxolan-2-yl)-2-nitrobutan-3-one p-toluenesulfonylhydrazone (89329-56-6) → 1-(2-methyl-1,3-dioxolan-2-yl)butan-3-one p-toluenesulfonylhydrazone (89329-60-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

DOI:10.1016/S0040-4020(01)88632-4

upstream raw materials:

1-(2-methyl-1,3-dioxolan-2yl)-2-nitrobutan-3-one

toluene-4-sulfonic acid hydrazide

2-methyl-2-(2-nitroethyl)-1,3-dioxolane

Downstream raw materials:

1-(2-methyl-1,3-dioxolan-2-yl)butan-3-one p-toluenesulfonylhydrazone

2,5-hexanedione