Oxo-[(3R,4R)-2-oxo-3-(2-phenoxy-acetylamino)-4-(2,2,2-trichloro-ethoxycarbonylsulfanyl)-azetidin-1-yl]-acetic acid benzyl ester

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Chemical Name:Oxo-[(3R,4R)-2-oxo-3-(2-phenoxy-acetylamino)-4-(2,2,2-trichloro-ethoxycarbonylsulfanyl)-azetidin-1-yl]-acetic acid benzyl ester
CAS No.:75029-79-7
Molecular Formula:C₂₃H₁₉Cl₃N₂O₈S
Molecular Weight:589.837
Hs Code.:

Synonyms:Oxo-[(3R,4R)-2-oxo-3-(2-phenoxy-acetylamino)-4-(2,2,2-trichloro-ethoxycarbonylsulfanyl)-azetidin-1-yl]-acetic acid benzyl ester

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Chemical Property of Oxo-[(3R,4R)-2-oxo-3-(2-phenoxy-acetylamino)-4-(2,2,2-trichloro-ethoxycarbonylsulfanyl)-azetidin-1-yl]-acetic acid benzyl ester

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Technology Process of Oxo-[(3R,4R)-2-oxo-3-(2-phenoxy-acetylamino)-4-(2,2,2-trichloro-ethoxycarbonylsulfanyl)-azetidin-1-yl]-acetic acid benzyl ester

There total 3 articles about Oxo-[(3R,4R)-2-oxo-3-(2-phenoxy-acetylamino)-4-(2,2,2-trichloro-ethoxycarbonylsulfanyl)-azetidin-1-yl]-acetic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 75029-78-6
3-Methyl-2-[(3R,4R)-2-oxo-3-(2-phenoxy-acetylamino)-4-(2,2,2-trichloro-ethoxycarbonylsulfanyl)-azetidin-1-yl]-but-2-enoic acid benzyl ester

: 75029-79-7
Oxo-[(3R,4R)-2-oxo-3-(2-phenoxy-acetylamino)-4-(2,2,2-trichloro-ethoxycarbonylsulfanyl)-azetidin-1-yl]-acetic acid benzyl ester

Guidance literature:: With ozone; In ethyl acetate; at -78 ℃;
DOI:10.1021/ja00539a046

Reference yield:

: 68047-65-4
(R)-2-[(2R)-2r-mercapto-4-oxo-3c-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-3-enoic acid benzyl ester

: 75029-79-7
Oxo-[(3R,4R)-2-oxo-3-(2-phenoxy-acetylamino)-4-(2,2,2-trichloro-ethoxycarbonylsulfanyl)-azetidin-1-yl]-acetic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / CH₂Cl₂

2: 100 percent / Et₃N / benzene

3: 77 percent / O₃ / ethyl acetate / -78 °C

With pyridine; ozone; triethylamine; In dichloromethane; ethyl acetate; benzene;
DOI:10.1021/ja00539a046

Reference yield:

: 75029-77-5
(R)-3-Methyl-2-[(3R,4R)-2-oxo-3-(2-phenoxy-acetylamino)-4-(2,2,2-trichloro-ethoxycarbonylsulfanyl)-azetidin-1-yl]-but-3-enoic acid benzyl ester

: 75029-79-7
Oxo-[(3R,4R)-2-oxo-3-(2-phenoxy-acetylamino)-4-(2,2,2-trichloro-ethoxycarbonylsulfanyl)-azetidin-1-yl]-acetic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / Et₃N / benzene

2: 77 percent / O₃ / ethyl acetate / -78 °C

With ozone; triethylamine; In ethyl acetate; benzene;
DOI:10.1021/ja00539a046