1-(6-(5-(2,6-difluorophenyl)-1H-indazol-3-yl)pyrazin-2-yl)piperidin-3-amine

Base Information

Chemical Name:1-(6-(5-(2,6-difluorophenyl)-1H-indazol-3-yl)pyrazin-2-yl)piperidin-3-amine
CAS No.:1380911-90-9
Molecular Formula:C₂₂H₂₀F₂N₆
Molecular Weight:406.438
Hs Code.:

Synonyms:1-(6-(5-(2,6-difluorophenyl)-1H-indazol-3-yl)pyrazin-2-yl)piperidin-3-amine

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Chemical Property of 1-(6-(5-(2,6-difluorophenyl)-1H-indazol-3-yl)pyrazin-2-yl)piperidin-3-amine

Chemical Property:

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Technology Process of 1-(6-(5-(2,6-difluorophenyl)-1H-indazol-3-yl)pyrazin-2-yl)piperidin-3-amine

There total 9 articles about 1-(6-(5-(2,6-difluorophenyl)-1H-indazol-3-yl)pyrazin-2-yl)piperidin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1380917-57-6
tert-butyl 1-(6-(5-(2,6-difluorophenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-3-yl)pyrazin-2-yl)piperidin-3-ylcarbamate

: 1380911-90-9
1-(6-(5-(2,6-difluorophenyl)-1H-indazol-3-yl)pyrazin-2-yl)piperidin-3-amine

Guidance literature:: With hydrogenchloride; In diethyl ether;
DOI:10.1016/j.bmcl.2014.12.068

Reference yield:

: 184637-48-7,172603-05-3
t-butyl piperidin-3-ylcarbamate

: 1380911-90-9
1-(6-(5-(2,6-difluorophenyl)-1H-indazol-3-yl)pyrazin-2-yl)piperidin-3-amine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide

2: lithium diisopropyl amide / tetrahydrofuran / 0 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide

4: hydrogenchloride / diethyl ether

With hydrogenchloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.12.068

Reference yield:

: 64248-56-2
1-bromo-2,6-difluorobenzene

: 1380911-90-9
1-(6-(5-(2,6-difluorophenyl)-1H-indazol-3-yl)pyrazin-2-yl)piperidin-3-amine

Guidance literature:: Multi-step reaction with 6 steps

1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene; water / 100 °C

2: hydrazine hydrate / 120 °C

3: iodine; potassium hydroxide / N,N-dimethyl-formamide / 20 °C

4: toluene-4-sulfonic acid / tetrahydrofuran / 70 °C

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide

6: hydrogenchloride / diethyl ether

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; sodium carbonate; toluene-4-sulfonic acid; hydrazine hydrate; potassium hydroxide; In tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide; toluene; 1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2014.12.068