3-(4-hydroxy-2-methoxyphenyl)-N-methoxy-N-methyl-2-(2,2,2-trifluoroacetamido)propanamide

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Chemical Name:3-(4-hydroxy-2-methoxyphenyl)-N-methoxy-N-methyl-2-(2,2,2-trifluoroacetamido)propanamide
CAS No.:1265501-12-9
Molecular Formula:C₁₄H₁₇F₃N₂O₅
Molecular Weight:350.295
Hs Code.:

Synonyms:3-(4-hydroxy-2-methoxyphenyl)-N-methoxy-N-methyl-2-(2,2,2-trifluoroacetamido)propanamide

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Chemical Property of 3-(4-hydroxy-2-methoxyphenyl)-N-methoxy-N-methyl-2-(2,2,2-trifluoroacetamido)propanamide

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Technology Process of 3-(4-hydroxy-2-methoxyphenyl)-N-methoxy-N-methyl-2-(2,2,2-trifluoroacetamido)propanamide

There total 3 articles about 3-(4-hydroxy-2-methoxyphenyl)-N-methoxy-N-methyl-2-(2,2,2-trifluoroacetamido)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 431-47-0
trifluoroacetic acid-methyl ester

: 1265501-11-8
tert-butyl 3-(4-hydroxy-2-methoxyphenyl)-1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate

: 1265501-12-9
3-(4-hydroxy-2-methoxyphenyl)-N-methoxy-N-methyl-2-(2,2,2-trifluoroacetamido)propanamide

Guidance literature:: tert-butyl 3-(4-hydroxy-2-methoxyphenyl)-1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate; With trifluoroacetic acid; In dichloromethane; for 4h;

trifluoroacetic acid-methyl ester; With triethylamine; In methanol; at 20 ℃; for 4h;
DOI:10.1021/jo102327e

Reference yield:

: 1259963-95-5
C₁₅H₂₁NO₆

: 1265501-12-9
3-(4-hydroxy-2-methoxyphenyl)-N-methoxy-N-methyl-2-(2,2,2-trifluoroacetamido)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 16 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 4 h

2.2: 4 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jo102327e

Reference yield:

: 1206547-02-5
C₂₁H₃₁NO₈

: 1265501-12-9
3-(4-hydroxy-2-methoxyphenyl)-N-methoxy-N-methyl-2-(2,2,2-trifluoroacetamido)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydrochloride monohydrate / tetrahydrofuran; water / 14 h / 20 °C

1.2: pH 1

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 16 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 4 h

3.2: 4 h / 20 °C

With lithium hydrochloride monohydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jo102327e