((2S,6R)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl-4-(3,4,5-trimethoxybenzamido)piperidin-1-ylphosphonochloridate

Base Information

Chemical Name:((2S,6R)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl-4-(3,4,5-trimethoxybenzamido)piperidin-1-ylphosphonochloridate
CAS No.:1351280-99-3
Molecular Formula:C₄₄H₄₉ClN₅O₉P
Molecular Weight:858.328
Hs Code.:

((2S,6R)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl-4-(3,4,5-trimethoxybenzamido)piperidin-1-ylphosphonochloridate

Synonyms:((2S,6R)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl-4-(3,4,5-trimethoxybenzamido)piperidin-1-ylphosphonochloridate

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Chemical Property of ((2S,6R)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl-4-(3,4,5-trimethoxybenzamido)piperidin-1-ylphosphonochloridate

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Technology Process of ((2S,6R)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl-4-(3,4,5-trimethoxybenzamido)piperidin-1-ylphosphonochloridate

There total 6 articles about ((2S,6R)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl-4-(3,4,5-trimethoxybenzamido)piperidin-1-ylphosphonochloridate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 914361-76-5
1-((2R,6S)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

: 1351280-98-2
C₁₅H₂₁Cl₂N₂O₅P

: 1351280-99-3
((2S,6R)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl-4-(3,4,5-trimethoxybenzamido)piperidin-1-ylphosphonochloridate

Guidance literature:: With 2,6-dimethylpyridine; dmap; In dichloromethane; at 0 - 20 ℃; for 18h;

Reference yield:

: 31648-51-8
4-(3,4,5-trimethoxybenzoyl)aminopiperidine

: 1351280-99-3
((2S,6R)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl-4-(3,4,5-trimethoxybenzamido)piperidin-1-ylphosphonochloridate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; trichlorophosphate / dichloromethane / -78 - 20 °C / Inert atmosphere

2: 2,6-dimethylpyridine; dmap / dichloromethane / 18 h / 0 - 20 °C

With 2,6-dimethylpyridine; dmap; triethylamine; trichlorophosphate; In dichloromethane;

Reference yield:

: 1298810-75-9
C₂₀H₃₀N₂O₆

: 1351280-99-3
((2S,6R)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl-4-(3,4,5-trimethoxybenzamido)piperidin-1-ylphosphonochloridate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane / 4 h

2: triethylamine; trichlorophosphate / dichloromethane / -78 - 20 °C / Inert atmosphere

3: 2,6-dimethylpyridine; dmap / dichloromethane / 18 h / 0 - 20 °C

With 2,6-dimethylpyridine; hydrogenchloride; dmap; triethylamine; trichlorophosphate; In 1,4-dioxane; dichloromethane;