alpha-(5-(4-Hydroxyphenyl)-3-isoxazolyl)-1-piperidineethanol

Base Information

Chemical Name:alpha-(5-(4-Hydroxyphenyl)-3-isoxazolyl)-1-piperidineethanol
CAS No.:53983-89-4
Molecular Formula:C₁₆H₂₀N₂O₃
Molecular Weight:288.346
Hs Code.:
DSSTox Substance ID:DTXSID90968802

Synonyms:p-Hydroxyperisoxal;BRN 0545761;1-Piperidineethanol, alpha-(5-(4-hydroxyphenyl)-3-isoxazolyl)-;3-(1-Hydroxy-2-piperidinoethyl)-5-(4-hydroxyphenyl)isoxazole;alpha-(5-(4-Hydroxyphenyl)-3-isoxazolyl)-1-piperidineethanol;53983-89-4;DTXSID90968802;LS-115436;4-{3-[1-Hydroxy-2-(piperidin-1-yl)ethyl]-1,2-oxazol-5(2H)-ylidene}cyclohexa-2,5-dien-1-one

Suppliers and Price of alpha-(5-(4-Hydroxyphenyl)-3-isoxazolyl)-1-piperidineethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
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Total 0 raw suppliers

Chemical Property of alpha-(5-(4-Hydroxyphenyl)-3-isoxazolyl)-1-piperidineethanol

Chemical Property:

Vapor Pressure:5.92E-11mmHg at 25°C
Boiling Point:473.5°C at 760 mmHg
Flash Point:240.1°C
Density:1.274g/cm³
XLogP3:1.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:288.14739250
Heavy Atom Count:21
Complexity:315

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCN(CC1)CC(C2=NOC(=C2)C3=CC=C(C=C3)O)O

Technology Process of alpha-(5-(4-Hydroxyphenyl)-3-isoxazolyl)-1-piperidineethanol

There total 10 articles about alpha-(5-(4-Hydroxyphenyl)-3-isoxazolyl)-1-piperidineethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7400-08-0,50940-26-6
para-coumaric acid

: 53983-89-4
4-[3-(1-hydroxy-2-piperidin-1-yl-ethyl)-isoxazol-5-yl]-phenol

Guidance literature:: Multi-step reaction with 5 steps

1: Cu / quinoline

2: propan-2-ol

3: (acetylation)

5: (i) acetone, (ii) NaBH₄, MeOH

With copper; In quinoline; isopropyl alcohol;
DOI:10.1248/cpb.24.1757

Reference yield:

: 39757-33-0
4-(4-hydroxy-phenyl)-2,4-dioxo-butyric acid methyl ester

: 53983-89-4
4-[3-(1-hydroxy-2-piperidin-1-yl-ethyl)-isoxazol-5-yl]-phenol

Guidance literature:: Multi-step reaction with 5 steps

1: aq. NH₂OH*0.5 H₂SO₄ / methanol / 0.25 h / Heating

2: Et₃N / diethyl ether; tetrahydrofuran

3: NaOAc / 2 h / 110 °C

4: Br₂ / CCl₄ / Ambient temperature

5: (i) acetone, (ii) NaBH₄, MeOH

With hydroxyammonium sulfate; bromine; sodium acetate; triethylamine; In tetrahydrofuran; methanol; tetrachloromethane; diethyl ether;
DOI:10.1248/cpb.24.1757

Reference yield:

: 60640-72-4
1-[5-(4-hydroxy-phenyl)-isoxazol-3-yl]-ethanone

: 53983-89-4
4-[3-(1-hydroxy-2-piperidin-1-yl-ethyl)-isoxazol-5-yl]-phenol

Guidance literature:: Multi-step reaction with 3 steps

1: NaOAc / 2 h / 110 °C

2: Br₂ / CCl₄ / Ambient temperature

3: (i) acetone, (ii) NaBH₄, MeOH

With bromine; sodium acetate; In tetrachloromethane;
DOI:10.1248/cpb.24.1757