7-Chloro-4-(3,5-dimethylpyrazol-1-yl)-2-(4-chlorobenzylthio)imidazo<4,5-d>pyridazine

Base Information

• Chemical Name: 7-Chloro-4-(3,5-dimethylpyrazol-1-yl)-2-(4-chlorobenzylthio)imidazo<4,5-d>pyridazine
• CAS No.: 85732-85-0
• Molecular Formula: C₁₇H₁₄Cl₂N₆S
• Molecular Weight: 405.31

Synonyms:7-Chloro-4-(3,5-dimethylpyrazol-1-yl)-2-(4-chlorobenzylthio)imidazo<4,5-d>pyridazine

Chemical Property of 7-Chloro-4-(3,5-dimethylpyrazol-1-yl)-2-(4-chlorobenzylthio)imidazo<4,5-d>pyridazine

Chemical Property:

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Technology Process of 7-Chloro-4-(3,5-dimethylpyrazol-1-yl)-2-(4-chlorobenzylthio)imidazo<4,5-d>pyridazine

There total 4 articles about 7-Chloro-4-(3,5-dimethylpyrazol-1-yl)-2-(4-chlorobenzylthio)imidazo<4,5-d>pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

7-Chloro-4-(3,5-dimethylpyrazol-1-yl)imidazo<4,5-d>pyridazine-2-thiol (85732-80-5) + 1-Chloro-4-(chloromethyl)benzene (104-83-6) → 7-Chloro-4-(3,5-dimethylpyrazol-1-yl)-2-(4-chlorobenzylthio)imidazo<4,5-d>pyridazine (85732-85-0)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; at 50 ℃; for 4h;

DOI:10.1002/jhet.5570200140

Reference yield:

3-Chloro-5-nitro-6-(3,5-dimethylpyrazol-1-yl)pyridazin-4-amine (85732-74-7) → 7-Chloro-4-(3,5-dimethylpyrazol-1-yl)-2-(4-chlorobenzylthio)imidazo<4,5-d>pyridazine (85732-85-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / H₂ / Raney nickel T-1 / ethanol / 760 Torr / Ambient temperature

2: 64 percent / sodium hydroxide/conc.HCl / pyridine / 3 h / 80 °C

3: 84 percent / potassium t-butoxide / dimethylformamide / 4 h / 50 °C

With hydrogenchloride; sodium hydroxide; potassium tert-butylate; hydrogen; Raney Nickel T-1; In pyridine; ethanol; N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570200140

Reference yield:

acetylacetone (123-54-6,81235-32-7) → 7-Chloro-4-(3,5-dimethylpyrazol-1-yl)-2-(4-chlorobenzylthio)imidazo<4,5-d>pyridazine (85732-85-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 88 percent / 10percent HCl / ethanol; H₂O / Heating

2: 90 percent / H₂ / Raney nickel T-1 / ethanol / 760 Torr / Ambient temperature

3: 64 percent / sodium hydroxide/conc.HCl / pyridine / 3 h / 80 °C

4: 84 percent / potassium t-butoxide / dimethylformamide / 4 h / 50 °C

With hydrogenchloride; sodium hydroxide; potassium tert-butylate; hydrogen; Raney Nickel T-1; In pyridine; ethanol; water; N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570200140

upstream raw materials:

7-Chloro-4-(3,5-dimethylpyrazol-1-yl)imidazo<4,5-d>pyridazine-2-thiol

1-Chloro-4-(chloromethyl)benzene

6-Chloro-3-(3,5-dimethylpyrazol-1-yl)pyridazine-4,5-diamine

3-Chloro-5-nitro-6-(3,5-dimethylpyrazol-1-yl)pyridazin-4-amine

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