4-cyano-N-methyl-N-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-yl)benzenesulfonamide

Base Information

Chemical Name:4-cyano-N-methyl-N-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-yl)benzenesulfonamide
CAS No.:1610610-46-2
Molecular Formula:C₂₂H₁₅F₃N₄O₂S
Molecular Weight:456.448
Hs Code.:

Synonyms:4-cyano-N-methyl-N-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-yl)benzenesulfonamide

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Chemical Property of 4-cyano-N-methyl-N-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-yl)benzenesulfonamide

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Technology Process of 4-cyano-N-methyl-N-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-yl)benzenesulfonamide

There total 7 articles about 4-cyano-N-methyl-N-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1610612-16-2
N-methyl-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridin-5-amine

: 49584-26-1
p-cyanobenzenesulfonyl chloride

: 1610610-46-2
4-cyano-N-methyl-N-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-yl)benzenesulfonamide

Guidance literature:: With pyridine; dmap; at 0 - 20 ℃;

Reference yield:

: 1610611-83-0
3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-carboxylic acid

: 1610610-46-2
4-cyano-N-methyl-N-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: diphenyl phosphoryl azide / toluene / 12 h / 80 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 4 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

4.1: dmap; pyridine / 0 - 20 °C

With pyridine; hydrogenchloride; dmap; diphenyl phosphoryl azide; sodium hydride; In 1,4-dioxane; N,N-dimethyl-formamide; toluene; 1.1: |Curtius Rearrangement;

Reference yield:

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: 1610610-46-2
4-cyano-N-methyl-N-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: O-(2,4-dinitrophenyl)hydroxylamine / N,N-dimethyl-formamide / 40 °C

1.2: 100 °C

2.1: water; sodium hydroxide / methanol; 1,4-dioxane / 3 h / 20 °C

3.1: diphenyl phosphoryl azide / toluene / 12 h / 80 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C

4.2: 4 h / 20 °C

5.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

6.1: dmap; pyridine / 0 - 20 °C

With pyridine; hydrogenchloride; dmap; diphenyl phosphoryl azide; water; sodium hydride; O-(2,4-dinitrophenyl)hydroxylamine; sodium hydroxide; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene; 3.1: |Curtius Rearrangement;