4'-(5-chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)-3'-fluoro-3-[(4-methoxybenzyl)oxy]-4H-1,2'-bipyridin-4-one

Base Information

Chemical Name:4'-(5-chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)-3'-fluoro-3-[(4-methoxybenzyl)oxy]-4H-1,2'-bipyridin-4-one
CAS No.:1333331-91-1
Molecular Formula:C₂₅H₁₈ClFN₄O₃
Molecular Weight:476.894
Hs Code.:

Synonyms:4'-(5-chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)-3'-fluoro-3-[(4-methoxybenzyl)oxy]-4H-1,2'-bipyridin-4-one

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Chemical Property of 4'-(5-chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)-3'-fluoro-3-[(4-methoxybenzyl)oxy]-4H-1,2'-bipyridin-4-one

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Technology Process of 4'-(5-chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)-3'-fluoro-3-[(4-methoxybenzyl)oxy]-4H-1,2'-bipyridin-4-one

There total 9 articles about 4'-(5-chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)-3'-fluoro-3-[(4-methoxybenzyl)oxy]-4H-1,2'-bipyridin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1333331-90-0
3'-fluoro-4'-iodo-3-[(4-methoxybenzyl)oxy]-4H-1,2'-bipyridin-4-one

: 1072152-34-1
5-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine

: 1333331-91-1
4'-(5-chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)-3'-fluoro-3-[(4-methoxybenzyl)oxy]-4H-1,2'-bipyridin-4-one

Guidance literature:: With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; at 18 - 135 ℃; for 0.25h; Sealed vial; Microwave irradiation;

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 1333331-91-1
4'-(5-chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)-3'-fluoro-3-[(4-methoxybenzyl)oxy]-4H-1,2'-bipyridin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 100 °C

2: ammonia / water / 18 h / 100 °C / Sealed glass tube

3: potassium carbonate / dimethyl sulfoxide / 48 h / 85 °C / Sealed vial

4: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 0.25 h / 18 - 135 °C / Sealed vial; Microwave irradiation

With ammonia; potassium carbonate; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 4: Suzuki Coupling;

Reference yield:

: 1219-33-6
5-(benzyloxy)-4-oxo-4H-pyran-2-carboxylic acid

: 1333331-91-1
4'-(5-chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)-3'-fluoro-3-[(4-methoxybenzyl)oxy]-4H-1,2'-bipyridin-4-one

Guidance literature:: Multi-step reaction with 6 steps

1: quinoline / 0.5 h / 235 °C / Reflux

2: hydrogenchloride / water / 2 h / Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 100 °C

4: ammonia / water / 18 h / 100 °C / Sealed glass tube

5: potassium carbonate / dimethyl sulfoxide / 48 h / 85 °C / Sealed vial

6: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 0.25 h / 18 - 135 °C / Sealed vial; Microwave irradiation

With quinoline; hydrogenchloride; ammonia; potassium carbonate; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 6: Suzuki Coupling;