(2E)-3-[4-[[1-[[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-imidazo[1,2-b]pyrazole-6-carbonyl]amino]cyclobutanecarbonyl]amino]phenyl]prop-2-enoic acid

Base Information

Chemical Name:(2E)-3-[4-[[1-[[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-imidazo[1,2-b]pyrazole-6-carbonyl]amino]cyclobutanecarbonyl]amino]phenyl]prop-2-enoic acid
CAS No.:1427549-56-1
Molecular Formula:C₃₃H₃₄FN₅O₄
Molecular Weight:583.662
Hs Code.:

(2E)-3-[4-[[1-[[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-imidazo[1,2-b]pyrazole-6-carbonyl]amino]cyclobutanecarbonyl]amino]phenyl]prop-2-enoic acid

Synonyms:(2E)-3-[4-[[1-[[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-imidazo[1,2-b]pyrazole-6-carbonyl]amino]cyclobutanecarbonyl]amino]phenyl]prop-2-enoic acid

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Chemical Property of (2E)-3-[4-[[1-[[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-imidazo[1,2-b]pyrazole-6-carbonyl]amino]cyclobutanecarbonyl]amino]phenyl]prop-2-enoic acid

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Technology Process of (2E)-3-[4-[[1-[[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-imidazo[1,2-b]pyrazole-6-carbonyl]amino]cyclobutanecarbonyl]amino]phenyl]prop-2-enoic acid

There total 9 articles about (2E)-3-[4-[[1-[[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-imidazo[1,2-b]pyrazole-6-carbonyl]amino]cyclobutanecarbonyl]amino]phenyl]prop-2-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1427549-55-0
ethyl (2E)-3-[4-({[1-({[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-1H-imidazo[1,2-b]pyrazole-6-yl]carbonyl}amino)cyclobutyl]carbonyl}amino)phenyl]prop-2-enoate

: 1427549-56-1
(2E)-3-[4-[[1-[[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-imidazo[1,2-b]pyrazole-6-carbonyl]amino]cyclobutanecarbonyl]amino]phenyl]prop-2-enoic acid

: methyl (E)-3-[4-[[1-[[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-imidazo[1,2-b]pyrazole-6-carbonyl]amino]cyclobutanecarbonyl]amino]phenyl]prop-2-enoate

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; methanol; at 60 ℃; for 2h;

Reference yield:

: 1427549-81-2
2-bromo-2-cyclohexyl-1-(4-fluorophenyl)ethanone

: 1427549-56-1
(2E)-3-[4-[[1-[[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-imidazo[1,2-b]pyrazole-6-carbonyl]amino]cyclobutanecarbonyl]amino]phenyl]prop-2-enoic acid

: methyl (E)-3-[4-[[1-[[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-imidazo[1,2-b]pyrazole-6-carbonyl]amino]cyclobutanecarbonyl]amino]phenyl]prop-2-enoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 75 °C

1.2: 2 h / 70 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 16 h

3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 60 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 60 °C

With water; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1427549-83-4
methyl 3-cyclohexyl-2-(4-fluorophenyl)-1H-imidazo[1,2-b]pyrazole-6-carboxylate

: 1427549-56-1
(2E)-3-[4-[[1-[[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-imidazo[1,2-b]pyrazole-6-carbonyl]amino]cyclobutanecarbonyl]amino]phenyl]prop-2-enoic acid

: methyl (E)-3-[4-[[1-[[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-imidazo[1,2-b]pyrazole-6-carbonyl]amino]cyclobutanecarbonyl]amino]phenyl]prop-2-enoate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h

2: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 60 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C

4: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 60 °C

With water; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;