5-(4-Dimethylamino-phenylsulfanylmethyl)-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:5-(4-Dimethylamino-phenylsulfanylmethyl)-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione
CAS No.:98808-29-8
Molecular Formula:C₁₈H₂₃N₃O₅S
Molecular Weight:393.464
Hs Code.:

Synonyms:5-(4-Dimethylamino-phenylsulfanylmethyl)-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione

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Chemical Property of 5-(4-Dimethylamino-phenylsulfanylmethyl)-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione

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Technology Process of 5-(4-Dimethylamino-phenylsulfanylmethyl)-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione

There total 6 articles about 5-(4-Dimethylamino-phenylsulfanylmethyl)-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.3%

: 5-(4-Dimethylamino-phenylsulfanylmethyl)-1-((2R,4S,5R)-4-p-tolyloxy-5-p-tolyloxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione

: 98808-29-8
5-(4-Dimethylamino-phenylsulfanylmethyl)-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione

Guidance literature:: With potassium carbonate; In methanol; for 48h; Ambient temperature;
DOI:10.1248/cpb.33.856

Reference yield:

: 4946-22-9,656242-02-3
N,N-dimethyl-4-aminothiophenol

: 98808-29-8
5-(4-Dimethylamino-phenylsulfanylmethyl)-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Na / 1.) MeOH, reflux, 1 h; 2.) room temp., 20 h

2: 69.3 percent / K₂CO₃ / methanol / 48 h / Ambient temperature

With sodium; potassium carbonate; In methanol;
DOI:10.1248/cpb.33.856

Reference yield:

: 52162-55-7
2-deoxy-3,5-di-O-(p-toluoyl)-D-erythro-pentofuranosyl chloride

: 98808-29-8
5-(4-Dimethylamino-phenylsulfanylmethyl)-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 46 percent / SnCl₄ / 1,2-dichloro-ethane / 2 h / Ambient temperature

2: HCl gas

3: 1.) Na / 1.) MeOH, reflux, 1 h; 2.) room temp., 20 h

4: 69.3 percent / K₂CO₃ / methanol / 48 h / Ambient temperature

With hydrogenchloride; sodium; tin(IV) chloride; potassium carbonate; In methanol; 1,2-dichloro-ethane;
DOI:10.1248/cpb.33.856