2-((3aS,4S,7aS)-6-Methoxycarbonyl-2-phenyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-yloxy)-malonic acid dimethyl ester

Base Information

• Chemical Name: 2-((3aS,4S,7aS)-6-Methoxycarbonyl-2-phenyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-yloxy)-malonic acid dimethyl ester
• CAS No.: 80631-81-8
• Molecular Formula: C₂₀H₂₂O₉
• Molecular Weight: 406.389
• Mol file: 80631-81-8.mol

Synonyms:2-((3aS,4S,7aS)-6-Methoxycarbonyl-2-phenyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-yloxy)-malonic acid dimethyl ester

Chemical Property of 2-((3aS,4S,7aS)-6-Methoxycarbonyl-2-phenyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-yloxy)-malonic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((3aS,4S,7aS)-6-Methoxycarbonyl-2-phenyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-yloxy)-malonic acid dimethyl ester

There total 6 articles about 2-((3aS,4S,7aS)-6-Methoxycarbonyl-2-phenyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-yloxy)-malonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (1α,5α,6α)-5--8-phenyl-7,9-dioxabicyclo<4.3.0>non-3-ene-3-carboxylate (80631-80-7,83889-53-6,83889-54-7) → 2-((3aS,4S,7aS)-6-Methoxycarbonyl-2-phenyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-yloxy)-malonic acid dimethyl ester (80631-81-8)

Guidance literature:

With zinc; In acetic acid; Yield given;

DOI:10.1021/ja00368a066

Reference yield:

mesoxalate de methyle (3298-40-6) → 2-((3aS,4S,7aS)-6-Methoxycarbonyl-2-phenyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-yloxy)-malonic acid dimethyl ester (80631-81-8)

Guidance literature:

Multi-step reaction with 3 steps

2: SOCl₂, pyridine / tetrahydrofuran

3: Zn / acetic acid

With pyridine; thionyl chloride; zinc; In tetrahydrofuran; acetic acid;

DOI:10.1021/ja00368a066

Reference yield:

methyl 4-epi-shikimate (4372-89-8,4372-91-2,14671-74-0,16613-43-7,16613-44-8,40983-58-2,121468-33-5,141781-68-2) → 2-((3aS,4S,7aS)-6-Methoxycarbonyl-2-phenyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-yloxy)-malonic acid dimethyl ester (80631-81-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 72 percent / TsOH / toluene / Heating

3: SOCl₂, pyridine / tetrahydrofuran

4: Zn / acetic acid

With pyridine; thionyl chloride; toluene-4-sulfonic acid; zinc; In tetrahydrofuran; acetic acid; toluene;

DOI:10.1021/ja00368a066

upstream raw materials:

methyl (1α,5α,6α)-5--8-phenyl-7,9-dioxabicyclo<4.3.0>non-3-ene-3-carboxylate

mesoxalate de methyle

methyl 4-epi-shikimate

benzaldehyde

Downstream raw materials:

2-((1R,5S,6S)-6-Benzoyloxy-5-bromo-3-methoxycarbonyl-cyclohex-2-enyloxy)-2-dimethylaminomethyl-malonic acid dimethyl ester

methyl (3β,4α,5β)-3-<<1-(methoxycarbonyl)ethenyl>oxy>-4-(benzoyloxy)-5-bromo-1-cyclohexene-1-carboxylate

dimethyl chlorismate

chorismic acid