2-Amino-1-cyclohexyl-4,5-diphenyl-1H-pyrrole-3-carboxylic acid amide

Base Information

• Chemical Name: 2-Amino-1-cyclohexyl-4,5-diphenyl-1H-pyrrole-3-carboxylic acid amide
• CAS No.: 77651-28-6
• Molecular Formula: C₂₃H₂₅N₃O
• Molecular Weight: 359.471
• Mol file: 77651-28-6.mol

Synonyms:2-Amino-1-cyclohexyl-4,5-diphenyl-1H-pyrrole-3-carboxylic acid amide

Chemical Property of 2-Amino-1-cyclohexyl-4,5-diphenyl-1H-pyrrole-3-carboxylic acid amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

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Technology Process of 2-Amino-1-cyclohexyl-4,5-diphenyl-1H-pyrrole-3-carboxylic acid amide

There total 1 articles about 2-Amino-1-cyclohexyl-4,5-diphenyl-1H-pyrrole-3-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-amino-1-cyclohexyl-4,5-diphenyl-1H-pyrrole-3-carbonitrile (55817-69-1) → 2-Amino-1-cyclohexyl-4,5-diphenyl-1H-pyrrole-3-carboxylic acid amide (77651-28-6)

Guidance literature:

With PPA; phosphoric acid; at 110 - 120 ℃; for 5h;

DOI:10.1002/ardp.19813140213

Reference yield: 95.0%

2-Amino-1-cyclohexyl-4,5-diphenyl-1H-pyrrole-3-carboxylic acid amide (77651-28-6) → C23H21N3OS (77651-43-5)

Guidance literature:

With disulfur dichloride; In hexane; for 3h; Heating;

DOI:10.1002/ardp.19813140213

Reference yield: 90.0%

4-methyl-benzaldehyde (104-87-0) + 2-Amino-1-cyclohexyl-4,5-diphenyl-1H-pyrrole-3-carboxylic acid amide (77651-28-6) → 7-cyclohexyl-2-(4-methylphenyl)-5,6-diphenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one (1221899-21-3)

Guidance literature:

With 1-methyl-3-(4-sulfobutyl)-1H-imidazol-3-ium hydrogensulfate; at 85 ℃; for 0.833333h;

DOI:10.1016/j.cclet.2009.09.002

upstream raw materials:

2-amino-1-cyclohexyl-4,5-diphenyl-1H-pyrrole-3-carbonitrile

Downstream raw materials:

C₂₃H₂₁N₃OS

7-cyclohexyl-2-(4-methylphenyl)-5,6-diphenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

2-(4-chlorophenyl)-7-cyclohexyl-5,6-diphenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

7-cyclohexyl-2-(4-methoxyphenyl)-5,6-diphenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one