(S)-tert-butyl 4-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)propionyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate

Base Information

Chemical Name:(S)-tert-butyl 4-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)propionyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate
CAS No.:1430217-69-8
Molecular Formula:C₃₁H₂₇ClN₆O₄
Molecular Weight:583.046
Hs Code.:

Synonyms:(S)-tert-butyl 4-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)propionyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate

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Chemical Property of (S)-tert-butyl 4-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)propionyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate

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Technology Process of (S)-tert-butyl 4-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)propionyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate

There total 5 articles about (S)-tert-butyl 4-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)propionyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 942318-49-2
3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)propiolic acid

: 1430217-30-3
(S)-tert-butyl 4-(1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate

: 1430217-69-8
(S)-tert-butyl 4-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)propionyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 24h;

Reference yield:

: 204317-99-7
(S)-2-(((9H-fluoren-9-yl)methoxy)carbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid

: 1430217-69-8
(S)-tert-butyl 4-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)propionyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; trichlorophosphate / dichloromethane / 1 h / 0 °C

2: morpholine / N,N-dimethyl-formamide / 0.5 h

3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h

With morpholine; pyridine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1430217-29-0
(S)-(9H-fluoren-9-yl)methyl 1-((4-(tert-butoxycarbonyl)phenyl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1430217-69-8
(S)-tert-butyl 4-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)propionyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: morpholine / N,N-dimethyl-formamide / 0.5 h

2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h

With morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;