N-[2-((5R,6R)-5-(tert-butyldimethylsilyloxy)-6-(3-(2,2-dimethoxyethyl)-2-iodo-6-methoxyphenoxy)cyclohex-1-enyl)]-N-methyl-2,4-dinitrobenzenesulfonamide

Base Information Edit

Chemical Name:N-[2-((5R,6R)-5-(tert-butyldimethylsilyloxy)-6-(3-(2,2-dimethoxyethyl)-2-iodo-6-methoxyphenoxy)cyclohex-1-enyl)]-N-methyl-2,4-dinitrobenzenesulfonamide
CAS No.:1257051-37-8
Molecular Formula:C₃₂H₄₆IN₃O₁₁SSi
Molecular Weight:835.787
Hs Code.:
Mol file:1257051-37-8.mol

N-[2-((5R,6R)-5-(tert-butyldimethylsilyloxy)-6-(3-(2,2-dimethoxyethyl)-2-iodo-6-methoxyphenoxy)cyclohex-1-enyl)]-N-methyl-2,4-dinitrobenzenesulfonamide

Synonyms:N-[2-((5R,6R)-5-(tert-butyldimethylsilyloxy)-6-(3-(2,2-dimethoxyethyl)-2-iodo-6-methoxyphenoxy)cyclohex-1-enyl)]-N-methyl-2,4-dinitrobenzenesulfonamide

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Chemical Property of N-[2-((5R,6R)-5-(tert-butyldimethylsilyloxy)-6-(3-(2,2-dimethoxyethyl)-2-iodo-6-methoxyphenoxy)cyclohex-1-enyl)]-N-methyl-2,4-dinitrobenzenesulfonamide Edit

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Technology Process of N-[2-((5R,6R)-5-(tert-butyldimethylsilyloxy)-6-(3-(2,2-dimethoxyethyl)-2-iodo-6-methoxyphenoxy)cyclohex-1-enyl)]-N-methyl-2,4-dinitrobenzenesulfonamide

There total 10 articles about N-[2-((5R,6R)-5-(tert-butyldimethylsilyloxy)-6-(3-(2,2-dimethoxyethyl)-2-iodo-6-methoxyphenoxy)cyclohex-1-enyl)]-N-methyl-2,4-dinitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 916225-97-3
2-iodo-6-methoxy-3-(2,2-dimethoxyethyl)phenol

: 1257051-36-7
N-[2-((5R,6S)-5-(tert-butyldimethylsilyloxy)-6-hydroxycyclohex-1-enyl)ethyl]-N-methyl-2,4-dinitrobenzenesulfonamide

: 1257051-37-8
N-[2-((5R,6R)-5-(tert-butyldimethylsilyloxy)-6-(3-(2,2-dimethoxyethyl)-2-iodo-6-methoxyphenoxy)cyclohex-1-enyl)]-N-methyl-2,4-dinitrobenzenesulfonamide

Guidance literature:: With tributylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 20 ℃; for 1h;
DOI:10.1002/asia.201000458

Reference yield:

: 2-iodo-4-methoxy-3-(methoxymethoxy)-1-(2-methoxyvinyl)benzene

: 1257051-37-8
N-[2-((5R,6R)-5-(tert-butyldimethylsilyloxy)-6-(3-(2,2-dimethoxyethyl)-2-iodo-6-methoxyphenoxy)cyclohex-1-enyl)]-N-methyl-2,4-dinitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: acetyl chloride / methanol / 1 h / 40 °C

2: tributylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 1 h / 20 °C

With tributylphosphine; acetyl chloride; diethylazodicarboxylate; In tetrahydrofuran; methanol; toluene; 2: Mitsunobu reaction;
DOI:10.1002/asia.201000458

Reference yield:

: 1257051-31-2
3-cyclopentenylpropyl methanesulfonate

: 1257051-37-8
N-[2-((5R,6R)-5-(tert-butyldimethylsilyloxy)-6-(3-(2,2-dimethoxyethyl)-2-iodo-6-methoxyphenoxy)cyclohex-1-enyl)]-N-methyl-2,4-dinitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: methanol / 3 h / Reflux

2.1: sodium hydrogencarbonate / dichloromethane; water / 0.5 h / 20 °C

3.1: ozone / toluene / 0 °C

3.2: 0.5 h / 20 °C

3.3: 2 h / 80 °C

4.1: trimethylsilyl trifluoromethanesulfonate; triethylamine / dichloromethane / 0.05 h / 0 °C

4.2: 0.5 h / 20 °C

5.1: pyridine / 1 h / 20 °C

6.1: lipase AK / tetrahydrofuran; water / 24 h / 20 °C / pH 7.41 / aq. phosphate buffer; Enzymatic reaction

6.2: 0.5 h / 0 °C

7.1: sodium tetrahydroborate; cerium(III) chloride heptahydrate / tetrahydrofuran / -40 - 0 °C

8.1: tributylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 1 h / 20 °C

With sodium tetrahydroborate; tributylphosphine; trimethylsilyl trifluoromethanesulfonate; cerium(III) chloride heptahydrate; sodium hydrogencarbonate; ozone; triethylamine; diethylazodicarboxylate; In tetrahydrofuran; pyridine; methanol; dichloromethane; water; toluene; 3.3: Aldol condensation / 4.2: Rubottom oxidation / 7.1: Luche reduction / 8.1: Mitsunobu reaction;
DOI:10.1002/asia.201000458