3-chloro-4-[1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-4-yl]benzamide

Base Information

Chemical Name:3-chloro-4-[1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-4-yl]benzamide
CAS No.:1616361-83-1
Molecular Formula:C₁₉H₁₈ClN₅OS
Molecular Weight:399.904
Hs Code.:

Synonyms:3-chloro-4-[1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-4-yl]benzamide

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Chemical Property of 3-chloro-4-[1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-4-yl]benzamide

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Technology Process of 3-chloro-4-[1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-4-yl]benzamide

There total 6 articles about 3-chloro-4-[1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-4-yl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1616359-65-9
methyl 3-chloro-4-[1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-4-yl]benzoate

: 1616361-83-1
3-chloro-4-[1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-4-yl]benzamide

Guidance literature:: With potassium cyanide; ammonia; In methanol; at 110 ℃; for 18h; Sealed tube;

Reference yield:

: 92406-50-3
1-methyl-3-(pyridin-2-yl)-1H-pyrazol-5-amine

: 1616361-83-1
3-chloro-4-[1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-4-yl]benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: acetonitrile / 0.33 h / 150 °C / Microwave irradiation

2: borane-THF / tetrahydrofuran / 2 h / Reflux

3: molybdenum hexacarbonyl; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); 1,8-diazabicyclo[5.4.0]undec-7-ene / methanol; acetonitrile / 1 h / 100 °C / Sealed tube; Microwave irradiation

4: potassium cyanide; ammonia / methanol / 18 h / 110 °C / Sealed tube

With potassium cyanide; borane-THF; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); ammonia; 1,8-diazabicyclo[5.4.0]undec-7-ene; molybdenum hexacarbonyl; In tetrahydrofuran; methanol; acetonitrile;

Reference yield:

: 1616360-05-4
4-(4-bromo-2-chlorophenyl)-1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepine

: 1616361-83-1
3-chloro-4-[1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-4-yl]benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: molybdenum hexacarbonyl; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); 1,8-diazabicyclo[5.4.0]undec-7-ene / methanol; acetonitrile / 1 h / 100 °C / Sealed tube; Microwave irradiation

2: potassium cyanide; ammonia / methanol / 18 h / 110 °C / Sealed tube

With potassium cyanide; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); ammonia; 1,8-diazabicyclo[5.4.0]undec-7-ene; molybdenum hexacarbonyl; In methanol; acetonitrile;