4-(4-chlorophenyl)-2-methyl-4-oxobutanenitrile

Base Information

Chemical Name:4-(4-chlorophenyl)-2-methyl-4-oxobutanenitrile
CAS No.:1360472-57-6
Molecular Formula:C₁₁H₁₀ClNO
Molecular Weight:207.659
Hs Code.:

Synonyms:4-(4-chlorophenyl)-2-methyl-4-oxobutanenitrile

Suppliers and Price of 4-(4-chlorophenyl)-2-methyl-4-oxobutanenitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 4-(4-chlorophenyl)-2-methyl-4-oxobutanenitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-(4-chlorophenyl)-2-methyl-4-oxobutanenitrile

There total 3 articles about 4-(4-chlorophenyl)-2-methyl-4-oxobutanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 95826-96-3
(E)-1-(4-chlorophenyl)-2-buten-1-one

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 1360472-57-6
4-(4-chlorophenyl)-2-methyl-4-oxobutanenitrile

Guidance literature:: With Br^(1-)*C₅₅H₅₁N₄O₃⁽¹⁺⁾; caesium carbonate; In chloroform; toluene; at 20 ℃; for 4h; optical yield given as %ee; enantioselective reaction;
DOI:10.1002/anie.201105536

Reference yield:

: 156909-45-4
C₁₀H₁₁ClO

: 1360472-57-6
4-(4-chlorophenyl)-2-methyl-4-oxobutanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: manganese(IV) oxide / diethyl ether / 24 h / 20 °C

2: Br^(1-)*C₅₅H₅₁N₄O₃⁽¹⁺⁾; caesium carbonate / chloroform; toluene / 4 h / 20 °C

With manganese(IV) oxide; Br^(1-)*C₅₅H₅₁N₄O₃⁽¹⁺⁾; caesium carbonate; In diethyl ether; chloroform; toluene;
DOI:10.1002/anie.201105536

Reference yield:

: 873-77-8
(4-chlorphenyl)magnesium bromide

: 1360472-57-6
4-(4-chlorophenyl)-2-methyl-4-oxobutanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 1 h / 0 °C

2: manganese(IV) oxide / diethyl ether / 24 h / 20 °C

3: Br^(1-)*C₅₅H₅₁N₄O₃⁽¹⁺⁾; caesium carbonate / chloroform; toluene / 4 h / 20 °C

With manganese(IV) oxide; Br^(1-)*C₅₅H₅₁N₄O₃⁽¹⁺⁾; caesium carbonate; In tetrahydrofuran; diethyl ether; chloroform; toluene;
DOI:10.1002/anie.201105536