4-((2-(2-hydroxyphenyl)quinolin-3-yl)methylamino)-3-nitro-5-sulfamoylbenzoic acid

Base Information

Chemical Name:4-((2-(2-hydroxyphenyl)quinolin-3-yl)methylamino)-3-nitro-5-sulfamoylbenzoic acid
CAS No.:1357063-79-6
Molecular Formula:C₂₃H₁₈N₄O₇S
Molecular Weight:494.485
Hs Code.:

Synonyms:4-((2-(2-hydroxyphenyl)quinolin-3-yl)methylamino)-3-nitro-5-sulfamoylbenzoic acid

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Chemical Property of 4-((2-(2-hydroxyphenyl)quinolin-3-yl)methylamino)-3-nitro-5-sulfamoylbenzoic acid

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Technology Process of 4-((2-(2-hydroxyphenyl)quinolin-3-yl)methylamino)-3-nitro-5-sulfamoylbenzoic acid

There total 6 articles about 4-((2-(2-hydroxyphenyl)quinolin-3-yl)methylamino)-3-nitro-5-sulfamoylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1357063-78-5
2-(3-(aminomethyl)quinolin-2-yl)phenol

: 22892-96-2
4-chloro-3-nitro-5-sulfamoylbenzoic acid

: 1357063-79-6
4-((2-(2-hydroxyphenyl)quinolin-3-yl)methylamino)-3-nitro-5-sulfamoylbenzoic acid

Guidance literature:: In butan-1-ol; at 80 - 90 ℃;
DOI:10.1016/j.bmc.2011.12.001

Reference yield:

: 1357063-72-9
2-(3-(hydroxymethyl)quinolin-2-yl)phenol

: 1357063-79-6
4-((2-(2-hydroxyphenyl)quinolin-3-yl)methylamino)-3-nitro-5-sulfamoylbenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide; triphenylphosphine / tetrachloromethane; N,N-dimethyl-formamide / 90 °C

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 4 h / 20 °C

3: butan-1-ol / 80 - 90 °C

With sodium azide; palladium 10% on activated carbon; hydrogen; triphenylphosphine; In tetrachloromethane; ethyl acetate; N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1016/j.bmc.2011.12.001

Reference yield:

: 1357063-76-3
2-(3-(azidomethyl)quinolin-2-yl)phenol

: 1357063-79-6
4-((2-(2-hydroxyphenyl)quinolin-3-yl)methylamino)-3-nitro-5-sulfamoylbenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 4 h / 20 °C

2: butan-1-ol / 80 - 90 °C

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; butan-1-ol;
DOI:10.1016/j.bmc.2011.12.001