(S)-3-[N-(3-methylbenzyl)-N-trifluoroacetyl]amino-2-(4-toluenesulfonyl)amino-1-propanol

Base Information

Chemical Name:(S)-3-[N-(3-methylbenzyl)-N-trifluoroacetyl]amino-2-(4-toluenesulfonyl)amino-1-propanol
CAS No.:199853-69-5
Molecular Formula:C₂₀H₂₃F₃N₂O₄S
Molecular Weight:444.475
Hs Code.:

Synonyms:(S)-3-[N-(3-methylbenzyl)-N-trifluoroacetyl]amino-2-(4-toluenesulfonyl)amino-1-propanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-[N-(3-methylbenzyl)-N-trifluoroacetyl]amino-2-(4-toluenesulfonyl)amino-1-propanol

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Technology Process of (S)-3-[N-(3-methylbenzyl)-N-trifluoroacetyl]amino-2-(4-toluenesulfonyl)amino-1-propanol

There total 10 articles about (S)-3-[N-(3-methylbenzyl)-N-trifluoroacetyl]amino-2-(4-toluenesulfonyl)amino-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 407-25-0
trifluoroacetic anhydride

: 199853-65-1
(S)-3-(3-methylbenzyl)amino-2-(4-toluenesulfonyl)amino-1-propanol

: 199853-69-5
(S)-3-[N-(3-methylbenzyl)-N-trifluoroacetyl]amino-2-(4-toluenesulfonyl)amino-1-propanol

Guidance literature:: With triethylamine; In chloroform; a) 5 deg C, 1 h, b) RT, 2 h;
DOI:10.1002/jhet.5570340516

Reference yield:

: 21753-19-5
2-(S)-p-toluenesulfonylamino-β-alanine

: 199853-69-5
(S)-3-[N-(3-methylbenzyl)-N-trifluoroacetyl]amino-2-(4-toluenesulfonyl)amino-1-propanol

Guidance literature:: Multi-step reaction with 7 steps

1: 96 percent / aq. NaOH / dioxane / 3 h / Ambient temperature

2: 99 percent / NaHCO₃ / dimethylformamide / 18 h / Ambient temperature

3: 89 percent / NaBH₄, LiCl / ethanol; tetrahydrofuran / 18 h / Ambient temperature

4: CF₃COOH / 1 h / Ambient temperature

5: NaHCO₃ / methanol / 4.5 h / Heating

6: NaBH₄ / tetrahydrofuran / 4 h / Ambient temperature

7: 97 percent / Et₃N / CHCl₃ / a) 5 deg C, 1 h, b) RT, 2 h

With sodium hydroxide; sodium tetrahydroborate; sodium hydrogencarbonate; triethylamine; trifluoroacetic acid; lithium chloride; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570340516

Reference yield:

: 36212-66-5
N²-(toluene-4-sulfonyl)-L-asparagine

: 199853-69-5
(S)-3-[N-(3-methylbenzyl)-N-trifluoroacetyl]amino-2-(4-toluenesulfonyl)amino-1-propanol

Guidance literature:: Multi-step reaction with 8 steps

1: 78 percent / Br₂, aq. NaOH / 0.25 h / 80 °C

2: 96 percent / aq. NaOH / dioxane / 3 h / Ambient temperature

3: 99 percent / NaHCO₃ / dimethylformamide / 18 h / Ambient temperature

4: 89 percent / NaBH₄, LiCl / ethanol; tetrahydrofuran / 18 h / Ambient temperature

5: CF₃COOH / 1 h / Ambient temperature

6: NaHCO₃ / methanol / 4.5 h / Heating

7: NaBH₄ / tetrahydrofuran / 4 h / Ambient temperature

8: 97 percent / Et₃N / CHCl₃ / a) 5 deg C, 1 h, b) RT, 2 h

With sodium hydroxide; sodium tetrahydroborate; bromine; sodium hydrogencarbonate; triethylamine; trifluoroacetic acid; lithium chloride; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570340516