1-cyclohexanecarbonyl-3-methoxy-1,2-dihydropyrazine

Base Information

Chemical Name:1-cyclohexanecarbonyl-3-methoxy-1,2-dihydropyrazine
CAS No.:1372607-34-5
Molecular Formula:C₁₂H₁₈N₂O₂
Molecular Weight:222.287
Hs Code.:

Synonyms:1-cyclohexanecarbonyl-3-methoxy-1,2-dihydropyrazine

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Chemical Property of 1-cyclohexanecarbonyl-3-methoxy-1,2-dihydropyrazine

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Technology Process of 1-cyclohexanecarbonyl-3-methoxy-1,2-dihydropyrazine

There total 1 articles about 1-cyclohexanecarbonyl-3-methoxy-1,2-dihydropyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 3149-28-8
2-methoxypyrazine

: 2719-27-9
cyclohexanylcarbonyl chloride

: 1372607-34-5
1-cyclohexanecarbonyl-3-methoxy-1,2-dihydropyrazine

Guidance literature:: With tri-n-butyl-tin hydride; In dichloromethane; at 0 ℃; for 0.25h; regioselective reaction; Inert atmosphere;
DOI:10.1021/jo202498r

Reference yield:

: 1372607-34-5
1-cyclohexanecarbonyl-3-methoxy-1,2-dihydropyrazine

: 55268-74-1,135526-78-2,57452-31-0,57452-98-9
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; water / tetrahydrofuran; methanol / 0.5 h / 0 °C / Inert atmosphere

2: caesium carbonate / tetrahydrofuran / 36 h / 80 °C / Inert atmosphere

3: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 18 h / 80 °C / Inert atmosphere

4: palladium on activated charcoal; hydrogen / methanol / 19 h / 20 °C / 760.05 Torr / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; water; hydrogen; caesium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 3: |Heck Reaction;
DOI:10.1016/j.tet.2017.10.006

Reference yield:

: 1372607-34-5
1-cyclohexanecarbonyl-3-methoxy-1,2-dihydropyrazine

: 98123-67-2,98123-83-2,98123-66-1,121654-56-6
2-(cyclohexylcarbonyl)-4-oxo-1,2,3,4,6,7,8,12b-octahydropyrazino[2,1-a][2]benzazepine

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; water / tetrahydrofuran; methanol / 0.5 h / 0 °C / Inert atmosphere

2: caesium carbonate / tetrahydrofuran / 16 h / 80 °C / Inert atmosphere

3: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 10 h / 80 °C / Inert atmosphere

4: hydrogen; platinum on activated charcoal / methanol / 24 h / 20 °C / 760.05 Torr / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; platinum on activated charcoal; water; hydrogen; caesium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 3: |Heck Reaction;
DOI:10.1016/j.tet.2017.10.006