3-{(2S)-1-[(1S,2R)-cis-1-tert-butyldimethylsilyloxy-7-isopropylindan-1-yl]-2-(N-p-toluenesulfonylindol-3-yl)-1,2,5,6-tetrahydropyridin-4-yl}pentan-3-ol

Base Information

• Chemical Name: 3-{(2S)-1-[(1S,2R)-cis-1-tert-butyldimethylsilyloxy-7-isopropylindan-1-yl]-2-(N-p-toluenesulfonylindol-3-yl)-1,2,5,6-tetrahydropyridin-4-yl}pentan-3-ol
• CAS No.: 1263054-46-1
• Molecular Formula: C₄₃H₅₈N₂O₄SSi
• Molecular Weight: 727.096
• Mol file: 1263054-46-1.mol

Synonyms:3-{(2S)-1-[(1S,2R)-cis-1-tert-butyldimethylsilyloxy-7-isopropylindan-1-yl]-2-(N-p-toluenesulfonylindol-3-yl)-1,2,5,6-tetrahydropyridin-4-yl}pentan-3-ol

Chemical Property of 3-{(2S)-1-[(1S,2R)-cis-1-tert-butyldimethylsilyloxy-7-isopropylindan-1-yl]-2-(N-p-toluenesulfonylindol-3-yl)-1,2,5,6-tetrahydropyridin-4-yl}pentan-3-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3-{(2S)-1-[(1S,2R)-cis-1-tert-butyldimethylsilyloxy-7-isopropylindan-1-yl]-2-(N-p-toluenesulfonylindol-3-yl)-1,2,5,6-tetrahydropyridin-4-yl}pentan-3-ol

There total 1 articles about 3-{(2S)-1-[(1S,2R)-cis-1-tert-butyldimethylsilyloxy-7-isopropylindan-1-yl]-2-(N-p-toluenesulfonylindol-3-yl)-1,2,5,6-tetrahydropyridin-4-yl}pentan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

ethyl (2S)-1-[(1S,2R)-cis-2-tert-butyldimethylsilyloxyl-7-isopropylindan-1-yl]-2-(N-p-toluenesulfonylindol-3-yl)-1,2,5,6-tetrahydropyridine-4-carboxylate (1263054-45-0) + ethylmagnesium bromide (925-90-6) → 3-{(2S)-1-[(1S,2R)-cis-1-tert-butyldimethylsilyloxy-7-isopropylindan-1-yl]-2-(N-p-toluenesulfonylindol-3-yl)-1,2,5,6-tetrahydropyridin-4-yl}pentan-3-ol (1263054-46-1)

Guidance literature:

In diethyl ether; at 0 ℃; for 3h;

DOI:10.1039/c0ob00627k

upstream raw materials:

ethyl (2S)-1-[(1S,2R)-cis-2-tert-butyldimethylsilyloxyl-7-isopropylindan-1-yl]-2-(N-p-toluenesulfonylindol-3-yl)-1,2,5,6-tetrahydropyridine-4-carboxylate

ethylmagnesium bromide