5-chloro-8-phenylisoquinoline

Base Information

Chemical Name:5-chloro-8-phenylisoquinoline
CAS No.:92426-42-1
Molecular Formula:C₁₅H₁₀ClN
Molecular Weight:239.704
Hs Code.:

Synonyms:5-chloro-8-phenylisoquinoline

Suppliers and Price of 5-chloro-8-phenylisoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-chloro-8-phenylisoquinoline

Chemical Property:

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Technology Process of 5-chloro-8-phenylisoquinoline

There total 4 articles about 5-chloro-8-phenylisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 927801-25-0
8-bromo-5-chloroisoquinoline

: 98-80-6
phenylboronic acid

: 92426-42-1
5-chloro-8-phenylisoquinoline

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; at 85 ℃; Schlenk technique; Inert atmosphere;
DOI:10.1055/s-0037-1609153

Reference yield:

: 5430-45-5
5-chloro-isoquinoline

: 92426-42-1
5-chloro-8-phenylisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid; N-Bromosuccinimide / 0 - 25 °C

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 85 °C / Schlenk technique; Inert atmosphere

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; sodium carbonate; In 1,2-dimethoxyethane; water; 2: |Suzuki Coupling;
DOI:10.1055/s-0037-1609153

Reference yield:

: 119-65-3
isoquinoline

: 92426-42-1
5-chloro-8-phenylisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid; trichloroisocyanuric acid / 24 h / 0 - 10 °C

2: sulfuric acid; N-Bromosuccinimide / 0 - 25 °C

3: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 85 °C / Schlenk technique; Inert atmosphere

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trichloroisocyanuric acid; sulfuric acid; sodium carbonate; In 1,2-dimethoxyethane; water; 3: |Suzuki Coupling;
DOI:10.1055/s-0037-1609153