2,2-Dimethyl-propionic acid (2R,3S,4S,5R,6R)-2-[5-(3-chlorocarbonyl-propyl)-3'-ethoxycarbonylmethyl-biphenyl-2-yloxy]-3,5-bis-(2,2-dimethyl-propionyloxy)-6-(2,2-dimethyl-propionyloxymethyl)-tetrahydro-pyran-4-yl ester

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Chemical Name:2,2-Dimethyl-propionic acid (2R,3S,4S,5R,6R)-2-[5-(3-chlorocarbonyl-propyl)-3'-ethoxycarbonylmethyl-biphenyl-2-yloxy]-3,5-bis-(2,2-dimethyl-propionyloxy)-6-(2,2-dimethyl-propionyloxymethyl)-tetrahydro-pyran-4-yl ester
CAS No.:187270-01-5
Molecular Formula:C₄₆H₆₃ClO₁₃
Molecular Weight:859.451
Hs Code.:

2,2-Dimethyl-propionic acid (2R,3S,4S,5R,6R)-2-[5-(3-chlorocarbonyl-propyl)-3'-ethoxycarbonylmethyl-biphenyl-2-yloxy]-3,5-bis-(2,2-dimethyl-propionyloxy)-6-(2,2-dimethyl-propionyloxymethyl)-tetrahydro-pyran-4-yl ester

Synonyms:2,2-Dimethyl-propionic acid (2R,3S,4S,5R,6R)-2-[5-(3-chlorocarbonyl-propyl)-3'-ethoxycarbonylmethyl-biphenyl-2-yloxy]-3,5-bis-(2,2-dimethyl-propionyloxy)-6-(2,2-dimethyl-propionyloxymethyl)-tetrahydro-pyran-4-yl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (2R,3S,4S,5R,6R)-2-[5-(3-chlorocarbonyl-propyl)-3'-ethoxycarbonylmethyl-biphenyl-2-yloxy]-3,5-bis-(2,2-dimethyl-propionyloxy)-6-(2,2-dimethyl-propionyloxymethyl)-tetrahydro-pyran-4-yl ester

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Technology Process of 2,2-Dimethyl-propionic acid (2R,3S,4S,5R,6R)-2-[5-(3-chlorocarbonyl-propyl)-3'-ethoxycarbonylmethyl-biphenyl-2-yloxy]-3,5-bis-(2,2-dimethyl-propionyloxy)-6-(2,2-dimethyl-propionyloxymethyl)-tetrahydro-pyran-4-yl ester

There total 3 articles about 2,2-Dimethyl-propionic acid (2R,3S,4S,5R,6R)-2-[5-(3-chlorocarbonyl-propyl)-3'-ethoxycarbonylmethyl-biphenyl-2-yloxy]-3,5-bis-(2,2-dimethyl-propionyloxy)-6-(2,2-dimethyl-propionyloxymethyl)-tetrahydro-pyran-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 187269-98-3
4-(3-(3-carboethoxymethylphenyl)-4-(2,3,4,6-tetra-O-pivaloyl-α-D-mannopyranosyloxy)phenyl)butanoic acid

: 187270-01-5
2,2-Dimethyl-propionic acid (2R,3S,4S,5R,6R)-2-[5-(3-chlorocarbonyl-propyl)-3'-ethoxycarbonylmethyl-biphenyl-2-yloxy]-3,5-bis-(2,2-dimethyl-propionyloxy)-6-(2,2-dimethyl-propionyloxymethyl)-tetrahydro-pyran-4-yl ester

Guidance literature:: With thionyl chloride; for 36h; Ambient temperature;
DOI:10.1021/jm9704917

Reference yield:

: 2,2-Dimethyl-propionic acid (2R,3R,4S,5S,6R)-3,5-bis-(2,2-dimethyl-propionyloxy)-2-(2,2-dimethyl-propionyloxymethyl)-6-(3'-ethoxycarbonylmethyl-biphenyl-2-yloxy)-tetrahydro-pyran-4-yl ester

: 187270-01-5
2,2-Dimethyl-propionic acid (2R,3S,4S,5R,6R)-2-[5-(3-chlorocarbonyl-propyl)-3'-ethoxycarbonylmethyl-biphenyl-2-yloxy]-3,5-bis-(2,2-dimethyl-propionyloxy)-6-(2,2-dimethyl-propionyloxymethyl)-tetrahydro-pyran-4-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 13.35 g / AlCl₃ / 1,2-dichloro-ethane / 0 - 20 °C

2: 97 percent / BF₃*Et₂O, TFA, Et₃SiH / CH₂Cl₂ / Ambient temperature

3: 99 percent / thionyl chloride / 36 h / Ambient temperature

With triethylsilane; aluminium trichloride; thionyl chloride; boron trifluoride diethyl etherate; trifluoroacetic acid; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jm9704917

Reference yield:

: 1054648-38-2
4-{3'-Ethoxycarbonylmethyl-6-[(2R,3S,4S,5R,6R)-3,4,5-tris-(2,2-dimethyl-propionyloxy)-6-(2,2-dimethyl-propionyloxymethyl)-tetrahydro-pyran-2-yloxy]-biphenyl-3-yl}-4-oxo-butyric acid

: 187270-01-5
2,2-Dimethyl-propionic acid (2R,3S,4S,5R,6R)-2-[5-(3-chlorocarbonyl-propyl)-3'-ethoxycarbonylmethyl-biphenyl-2-yloxy]-3,5-bis-(2,2-dimethyl-propionyloxy)-6-(2,2-dimethyl-propionyloxymethyl)-tetrahydro-pyran-4-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / BF₃*Et₂O, TFA, Et₃SiH / CH₂Cl₂ / Ambient temperature

2: 99 percent / thionyl chloride / 36 h / Ambient temperature

With triethylsilane; thionyl chloride; boron trifluoride diethyl etherate; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm9704917