(R)-7-(4-Fluoro-phenyl)-7-(6-hydroxy-4,7-dimethyl-indan-5-yl)-heptanoic acid methyl ester

Base Information

• Chemical Name: (R)-7-(4-Fluoro-phenyl)-7-(6-hydroxy-4,7-dimethyl-indan-5-yl)-heptanoic acid methyl ester
• CAS No.: 156558-05-3
• Molecular Formula: C₂₅H₃₁FO₃
• Molecular Weight: 398.518
• Mol file: 156558-05-3.mol

Synonyms:(R)-7-(4-Fluoro-phenyl)-7-(6-hydroxy-4,7-dimethyl-indan-5-yl)-heptanoic acid methyl ester

Chemical Property of (R)-7-(4-Fluoro-phenyl)-7-(6-hydroxy-4,7-dimethyl-indan-5-yl)-heptanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (R)-7-(4-Fluoro-phenyl)-7-(6-hydroxy-4,7-dimethyl-indan-5-yl)-heptanoic acid methyl ester

There total 1 articles about (R)-7-(4-Fluoro-phenyl)-7-(6-hydroxy-4,7-dimethyl-indan-5-yl)-heptanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-hydroxy-4,7-dimethylindan (28567-20-6) + methyl (S)-7-(4-fluorophenyl)-7-hydroxyheptanoate (156558-16-6) → (R)-7-(4-Fluoro-phenyl)-7-(6-hydroxy-4,7-dimethyl-indan-5-yl)-heptanoic acid methyl ester (156558-05-3) + (S)-7-(4-Fluoro-phenyl)-7-(6-hydroxy-4,7-dimethyl-indan-5-yl)-heptanoic acid methyl ester

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In 1,2-dichloro-ethane; at 10 ℃; for 1h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1248/cpb.44.749

Reference yield: 79.0%

(R)-7-(4-Fluoro-phenyl)-7-(6-hydroxy-4,7-dimethyl-indan-5-yl)-heptanoic acid methyl ester (156558-05-3) → (R)-7-(4-fluorophenyl)-7-(6-hydroxy-4,7-dimethylindan-5-yl)heptanoic acid

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; for 14h; Ambient temperature;

DOI:10.1248/cpb.44.749

upstream raw materials:

5-hydroxy-4,7-dimethylindan

methyl (S)-7-(4-fluorophenyl)-7-hydroxyheptanoate