2,2-dimethoxy-3-(2-oxoethyl)cyclohexanecarboxylic acid ethyl ester

Base Information

• Chemical Name: 2,2-dimethoxy-3-(2-oxoethyl)cyclohexanecarboxylic acid ethyl ester
• CAS No.: 1007229-42-6
• Molecular Formula: C₁₃H₂₂O₅
• Molecular Weight: 258.315
• Mol file: 1007229-42-6.mol

Synonyms:2,2-dimethoxy-3-(2-oxoethyl)cyclohexanecarboxylic acid ethyl ester

Chemical Property of 2,2-dimethoxy-3-(2-oxoethyl)cyclohexanecarboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 2,2-dimethoxy-3-(2-oxoethyl)cyclohexanecarboxylic acid ethyl ester

There total 1 articles about 2,2-dimethoxy-3-(2-oxoethyl)cyclohexanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

3-allyl-2,2-dimethoxycyclohexanecarboxylic acid ethyl ester (1007229-41-5) → 2,2-dimethoxy-3-(2-oxoethyl)cyclohexanecarboxylic acid ethyl ester (1007229-42-6)

Guidance literature:

3-allyl-2,2-dimethoxycyclohexanecarboxylic acid ethyl ester; With ozone; In dichloromethane; at -78 ℃; for 0.5h;

With triphenylphosphine; In dichloromethane; at 20 ℃; for 8h; Further stages.;

DOI:10.1002/anie.200703022

Reference yield: 94.0%

2,2-dimethoxy-3-(2-oxoethyl)cyclohexanecarboxylic acid ethyl ester (1007229-42-6) + Ethyl 2-methyl-2-(phenylseleno)propionate (76893-72-6) → 3-[3-ethoxycarbonyl-2-hydroxy-3-(phenylseleno)butyl]-2,2-dimethoxycyclohexanecarboxylic acid ethyl ester (1007229-43-7)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 4h;

DOI:10.1002/anie.200703022

upstream raw materials:

3-allyl-2,2-dimethoxycyclohexanecarboxylic acid ethyl ester

Downstream raw materials:

3-[3-ethoxycarbonyl-2-hydroxy-3-(phenylseleno)butyl]-2,2-dimethoxycyclohexanecarboxylic acid ethyl ester