4-(2-hydroxy-5-brominebenzylideneamino)-3-(2-hydroxyphenyl)-1,2,4-triazole-5-thione

Base Information

• Chemical Name: 4-(2-hydroxy-5-brominebenzylideneamino)-3-(2-hydroxyphenyl)-1,2,4-triazole-5-thione
• CAS No.: 1428325-19-2
• Molecular Formula: C₁₅H₁₁BrN₄O₂S
• Molecular Weight: 391.248

Synonyms:4-(2-hydroxy-5-brominebenzylideneamino)-3-(2-hydroxyphenyl)-1,2,4-triazole-5-thione

Chemical Property of 4-(2-hydroxy-5-brominebenzylideneamino)-3-(2-hydroxyphenyl)-1,2,4-triazole-5-thione

Chemical Property:

Purity/Quality:

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Technology Process of 4-(2-hydroxy-5-brominebenzylideneamino)-3-(2-hydroxyphenyl)-1,2,4-triazole-5-thione

There total 2 articles about 4-(2-hydroxy-5-brominebenzylideneamino)-3-(2-hydroxyphenyl)-1,2,4-triazole-5-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-amino-2,4-dihydro-5-(2-hydroxyphenyl)-3H-1,2,4-triazole-3-thione (22706-15-6) + 5-bromosalicyclaldehyde (1761-61-1) → 4-(2-hydroxy-5-brominebenzylideneamino)-3-(2-hydroxyphenyl)-1,2,4-triazole-5-thione (1428325-19-2)

Guidance literature:

In ethanol; Reflux;

DOI:10.1016/j.bmcl.2013.02.038

Reference yield:

methyl salicylate (119-36-8,8024-54-2) → 4-(2-hydroxy-5-brominebenzylideneamino)-3-(2-hydroxyphenyl)-1,2,4-triazole-5-thione (1428325-19-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrazine hydrate / Reflux

2.1: potassium hydroxide

2.2: Reflux

3.1: ethanol / Reflux

With hydrazine hydrate; potassium hydroxide; In ethanol;

DOI:10.1016/j.bmcl.2013.02.038

Reference yield: 63.0%

4-(2-hydroxy-5-brominebenzylideneamino)-3-(2-hydroxyphenyl)-1,2,4-triazole-5-thione (1428325-19-2) + 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide (572-09-8) → C29H29BrN4O11S

Guidance literature:

With potassium hydroxide; In water; acetone; at 20 ℃; for 8h;

DOI:10.1016/j.bmcl.2013.02.038

upstream raw materials:

4-amino-2,4-dihydro-5-(2-hydroxyphenyl)-3H-1,2,4-triazole-3-thione

5-bromosalicyclaldehyde

methyl salicylate

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