3-(4-Fluoro-benzyl)-2-methoxy-1-methyl-2,3-dihydro-1H-benzo[1,3,2]diazaphosphinin-4-one

Base Information

• Chemical Name: 3-(4-Fluoro-benzyl)-2-methoxy-1-methyl-2,3-dihydro-1H-benzo[1,3,2]diazaphosphinin-4-one
• CAS No.: 212266-62-1
• Molecular Formula: C₁₆H₁₆FN₂O₂P
• Molecular Weight: 318.287
• Mol file: 212266-62-1.mol

Synonyms:3-(4-Fluoro-benzyl)-2-methoxy-1-methyl-2,3-dihydro-1H-benzo[1,3,2]diazaphosphinin-4-one

Chemical Property of 3-(4-Fluoro-benzyl)-2-methoxy-1-methyl-2,3-dihydro-1H-benzo[1,3,2]diazaphosphinin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 3-(4-Fluoro-benzyl)-2-methoxy-1-methyl-2,3-dihydro-1H-benzo[1,3,2]diazaphosphinin-4-one

There total 1 articles about 3-(4-Fluoro-benzyl)-2-methoxy-1-methyl-2,3-dihydro-1H-benzo[1,3,2]diazaphosphinin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.2%

Trimethylmethoxysilane (1825-61-2) + 2-Chloro-3-(4-fluoro-benzyl)-1-methyl-2,3-dihydro-1H-benzo[1,3,2]diazaphosphinin-4-one → 3-(4-Fluoro-benzyl)-2-methoxy-1-methyl-2,3-dihydro-1H-benzo[1,3,2]diazaphosphinin-4-one (212266-62-1)

Guidance literature:

In dichloromethane; for 7h;

DOI:10.1080/10426509708043542

Reference yield: 86.1%

3-(4-Fluoro-benzyl)-2-methoxy-1-methyl-2,3-dihydro-1H-benzo[1,3,2]diazaphosphinin-4-one (212266-62-1) → 2-Chloro-3-(4-fluoro-benzyl)-1-methyl-2-oxo-2,3-dihydro-1H-2λ5-benzo[1,3,2]diazaphosphinin-4-one (212266-63-2)

Guidance literature:

With sulfuryl dichloride; In dichloromethane; for 18h; Ambient temperature;

DOI:10.1080/10426509708043542

Reference yield:

3-(4-Fluoro-benzyl)-2-methoxy-1-methyl-2,3-dihydro-1H-benzo[1,3,2]diazaphosphinin-4-one (212266-62-1) → 2-[Bis-(2-chloro-ethyl)-amino]-3-(4-fluoro-benzyl)-1-methyl-2-oxo-2,3-dihydro-1H-2λ5-benzo[1,3,2]diazaphosphinin-4-one

Guidance literature:

Multi-step reaction with 2 steps

1: 86.1 percent / SO₂Cl₂ / CH₂Cl₂ / 18 h / Ambient temperature

2: 36 percent / Et₃N / CH₂Cl₂ / 18 h

With sulfuryl dichloride; triethylamine; In dichloromethane;

DOI:10.1080/10426509708043542

upstream raw materials:

Trimethylmethoxysilane

Downstream raw materials:

2-Chloro-3-(4-fluoro-benzyl)-1-methyl-2-oxo-2,3-dihydro-1H-2λ⁵-benzo[1,3,2]diazaphosphinin-4-one