Technology Process of α4,3-O-isopropylidene-α5-deoxy-α5-[diethyl(1'-fluoro-1'-phenylsulfonyl)phosphonomethyl]pyridoxine
There total 2 articles about α4,3-O-isopropylidene-α5-deoxy-α5-[diethyl(1'-fluoro-1'-phenylsulfonyl)phosphonomethyl]pyridoxine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
phosphonic acid diethyl ester;
With
potassium hexamethylsilazane;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; toluene;
at -78 ℃;
for 0.0833333h;
α4,3-O-isopropylidene-α5-pyridoxyl chloride;
With
tetra-(n-butyl)ammonium iodide;
In
tetrahydrofuran; dichloromethane; toluene;
at -78 ℃;
Further stages.;
DOI:10.1021/ol015983z
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: Et3N; DMAP; methanesulfonyl chloride / CH2Cl2 / 1 h / 0 °C
2.1: KHMDS / tetrahydrofuran; toluene; hexamethylphosphoric acid triamide / 0.08 h / -78 °C
2.2: 108 mg / tetrabutylammonium iodide / tetrahydrofuran; CH2Cl2; toluene / -78 °C
With
dmap; potassium hexamethylsilazane; methanesulfonyl chloride; triethylamine;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; toluene;
DOI:10.1021/ol015983z
