α⁴,3-O-isopropylidene-α⁵-deoxy-α⁵-[diethyl(1'-fluoro-1'-phenylsulfonyl)phosphonomethyl]pyridoxine

Base Information

• Chemical Name: α⁴,3-O-isopropylidene-α⁵-deoxy-α⁵-[diethyl(1'-fluoro-1'-phenylsulfonyl)phosphonomethyl]pyridoxine
• CAS No.: 352438-93-8
• Molecular Formula: C₂₂H₂₉FNO₇PS
• Molecular Weight: 501.513

Synonyms:α⁴,3-O-isopropylidene-α⁵-deoxy-α⁵-[diethyl(1'-fluoro-1'-phenylsulfonyl)phosphonomethyl]pyridoxine

Chemical Property of α⁴,3-O-isopropylidene-α⁵-deoxy-α⁵-[diethyl(1'-fluoro-1'-phenylsulfonyl)phosphonomethyl]pyridoxine

Chemical Property:

Purity/Quality:

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Technology Process of α⁴,3-O-isopropylidene-α⁵-deoxy-α⁵-[diethyl(1'-fluoro-1'-phenylsulfonyl)phosphonomethyl]pyridoxine

There total 2 articles about α⁴,3-O-isopropylidene-α⁵-deoxy-α⁵-[diethyl(1'-fluoro-1'-phenylsulfonyl)phosphonomethyl]pyridoxine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

α4,3-O-isopropylidene-α5-pyridoxyl chloride (14142-90-6) + phosphonic acid diethyl ester (135789-87-6,114968-97-7) → α4,3-O-isopropylidene-α5-deoxy-α5-[diethyl(1'-fluoro-1'-phenylsulfonyl)phosphonomethyl]pyridoxine (352438-93-8)

Guidance literature:

phosphonic acid diethyl ester; With potassium hexamethylsilazane; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; toluene; at -78 ℃; for 0.0833333h;

α⁴,3-O-isopropylidene-α⁵-pyridoxyl chloride; With tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; dichloromethane; toluene; at -78 ℃; Further stages.;

DOI:10.1021/ol015983z

Reference yield:

(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol (1136-52-3) → α4,3-O-isopropylidene-α5-deoxy-α5-[diethyl(1'-fluoro-1'-phenylsulfonyl)phosphonomethyl]pyridoxine (352438-93-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Et₃N; DMAP; methanesulfonyl chloride / CH₂Cl₂ / 1 h / 0 °C

2.1: KHMDS / tetrahydrofuran; toluene; hexamethylphosphoric acid triamide / 0.08 h / -78 °C

2.2: 108 mg / tetrabutylammonium iodide / tetrahydrofuran; CH₂Cl₂; toluene / -78 °C

With dmap; potassium hexamethylsilazane; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; toluene;

DOI:10.1021/ol015983z

upstream raw materials:

α⁴,3-O-isopropylidene-α⁵-pyridoxyl chloride

phosphonic acid diethyl ester

(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol

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