2-(2,6-dibromophenyl)-7-{[2-fluoro-6-(trifluoromethyl)phenyl]ethynyl}-4,4-dimethyl-1,4-dihydrochromeno[3,4-d]imidazole

Base Information

Chemical Name:2-(2,6-dibromophenyl)-7-{[2-fluoro-6-(trifluoromethyl)phenyl]ethynyl}-4,4-dimethyl-1,4-dihydrochromeno[3,4-d]imidazole
CAS No.:1393843-57-6
Molecular Formula:C₂₇H₁₆Br₂F₄N₂O
Molecular Weight:620.238
Hs Code.:

Synonyms:2-(2,6-dibromophenyl)-7-{[2-fluoro-6-(trifluoromethyl)phenyl]ethynyl}-4,4-dimethyl-1,4-dihydrochromeno[3,4-d]imidazole

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Chemical Property of 2-(2,6-dibromophenyl)-7-{[2-fluoro-6-(trifluoromethyl)phenyl]ethynyl}-4,4-dimethyl-1,4-dihydrochromeno[3,4-d]imidazole

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Technology Process of 2-(2,6-dibromophenyl)-7-{[2-fluoro-6-(trifluoromethyl)phenyl]ethynyl}-4,4-dimethyl-1,4-dihydrochromeno[3,4-d]imidazole

There total 7 articles about 2-(2,6-dibromophenyl)-7-{[2-fluoro-6-(trifluoromethyl)phenyl]ethynyl}-4,4-dimethyl-1,4-dihydrochromeno[3,4-d]imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1393843-41-8
2-(2,6-dibromophenyl)-7-ethynyl-4,4-dimethyl-1,4-dihydrochromeno[3,4-d]imidazole

: 110192-40-0
2-iodo-3-fluorobenzotrifluoride

: 1393843-57-6
2-(2,6-dibromophenyl)-7-{[2-fluoro-6-(trifluoromethyl)phenyl]ethynyl}-4,4-dimethyl-1,4-dihydrochromeno[3,4-d]imidazole

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; tetrabutyl ammonium fluoride; In dimethyl sulfoxide; Heating;
DOI:10.1016/j.bmcl.2017.03.068

Reference yield:

: 1393843-38-3
2,2-dimethyl-7-trimethylsilanylethynyl-chroman-4-one

: 1393843-57-6
2-(2,6-dibromophenyl)-7-{[2-fluoro-6-(trifluoromethyl)phenyl]ethynyl}-4,4-dimethyl-1,4-dihydrochromeno[3,4-d]imidazole

Guidance literature:: Multi-step reaction with 4 steps

1: tetrabutyl ammonium fluoride / 20 °C

2: isopentyl nitrite; hydrogenchloride / 20 °C

3: acetic acid; ammonium acetate / 100 °C

4: bis-triphenylphosphine-palladium(II) chloride; tetrabutyl ammonium fluoride / dimethyl sulfoxide / Heating

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; ammonium acetate; tetrabutyl ammonium fluoride; acetic acid; isopentyl nitrite; In dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2017.03.068

Reference yield:

: 39730-66-0
1-(2-hydroxy-4-iodophenyl)ethan-1-one

: 1393843-57-6
2-(2,6-dibromophenyl)-7-{[2-fluoro-6-(trifluoromethyl)phenyl]ethynyl}-4,4-dimethyl-1,4-dihydrochromeno[3,4-d]imidazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyrrolidine / methanol / 0 - 5 °C

1.2: 20 °C / Reflux

2.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / dimethyl sulfoxide

3.1: tetrabutyl ammonium fluoride / 20 °C

4.1: isopentyl nitrite; hydrogenchloride / 20 °C

5.1: acetic acid; ammonium acetate / 100 °C

6.1: bis-triphenylphosphine-palladium(II) chloride; tetrabutyl ammonium fluoride / dimethyl sulfoxide / Heating

With pyrrolidine; hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; ammonium acetate; tetrabutyl ammonium fluoride; acetic acid; triethylamine; isopentyl nitrite; In methanol; dimethyl sulfoxide; 2.1: |Sonogashira Cross-Coupling;
DOI:10.1016/j.bmcl.2017.03.068