N-[2-(6-Fluoro-2-methyl-chroman-8-yloxy)-ethyl]-3-(4-methoxy-phenyl)-propionamide

Base Information

Chemical Name:N-[2-(6-Fluoro-2-methyl-chroman-8-yloxy)-ethyl]-3-(4-methoxy-phenyl)-propionamide
CAS No.:153958-36-2
Molecular Formula:C₂₂H₂₆FNO₄
Molecular Weight:387.451
Hs Code.:

Synonyms:N-[2-(6-Fluoro-2-methyl-chroman-8-yloxy)-ethyl]-3-(4-methoxy-phenyl)-propionamide

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Chemical Property of N-[2-(6-Fluoro-2-methyl-chroman-8-yloxy)-ethyl]-3-(4-methoxy-phenyl)-propionamide

Chemical Property:

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Technology Process of N-[2-(6-Fluoro-2-methyl-chroman-8-yloxy)-ethyl]-3-(4-methoxy-phenyl)-propionamide

There total 4 articles about N-[2-(6-Fluoro-2-methyl-chroman-8-yloxy)-ethyl]-3-(4-methoxy-phenyl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6-Fluoro-2-methyl-chroman-8-ol

: 153958-36-2
N-[2-(6-Fluoro-2-methyl-chroman-8-yloxy)-ethyl]-3-(4-methoxy-phenyl)-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1: aq. NaOH, n-Bu₄NHSO₄ / 70 °C

2: acetonitrile / 3 h / Heating

3: HCOOH / 10percent Pd/C / methanol / 1 h / Ambient temperature

4: Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

With sodium hydroxide; formic acid; tetra(n-butyl)ammonium hydrogensulfate; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; acetonitrile;
DOI:10.1021/jm9707840

Reference yield:

: 153958-33-9
8-(2-bromoethoxy)-6-fluoro-2-methylchroman

: 153958-36-2
N-[2-(6-Fluoro-2-methyl-chroman-8-yloxy)-ethyl]-3-(4-methoxy-phenyl)-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile / 3 h / Heating

2: HCOOH / 10percent Pd/C / methanol / 1 h / Ambient temperature

3: Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

With formic acid; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; acetonitrile;
DOI:10.1021/jm9707840

Reference yield:

: 153958-34-0
Benzyl-[2-(6-fluoro-2-methyl-chroman-8-yloxy)-ethyl]-amine

: 153958-36-2
N-[2-(6-Fluoro-2-methyl-chroman-8-yloxy)-ethyl]-3-(4-methoxy-phenyl)-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: HCOOH / 10percent Pd/C / methanol / 1 h / Ambient temperature

2: Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

With formic acid; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm9707840