Bromotopsentin

Base Information

Chemical Name:Bromotopsentin
CAS No.:112515-44-3
Molecular Formula:C₂₀H₁₃BrN₄O₂
Molecular Weight:421.253
Hs Code.:
Mol file:112515-44-3.mol

Synonyms:Bromotopsentin;Topsentin B2;

Suppliers and Price of Bromotopsentin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Bromotopsentin

Chemical Property:

Vapor Pressure:3.22E-28mmHg at 25°C
Boiling Point:822.5°C at 760 mmHg
Flash Point:451.2°C
PSA：97.56000
Density:1.727g/cm³
LogP:4.73840

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Bromotopsentin

There total 10 articles about Bromotopsentin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1038921-30-0
[4-(6-bromo-1H-indol-3-yl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-(6-methoxymethoxy-1H-indol-3-yl)-methanone

: 112515-44-3
Bromotopsentin

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; for 14h; Heating;
DOI:10.1016/j.tet.2008.04.045

Reference yield: 68.0%

: 1038921-34-4
[4-(6-bromo-1H-indol-3-yl)-1-benzyloxymethyl-1H-imidazol-2-yl]-(6-methoxymethoxy-1H-indol-3-yl)-methanone

: 112515-44-3
Bromotopsentin

Guidance literature:: With hydrogenchloride; In ethanol; for 14h; Heating;
DOI:10.1016/j.tet.2008.04.045

Reference yield:

: 180633-65-2
6-methoxymethoxy-1H-indole

: 112515-44-3
Bromotopsentin

Guidance literature:: Multi-step reaction with 7 steps

1: KOH, I₂ / dimethylformamide / Ambient temperature

2: NaH / dimethylformamide; tetrahydrofuran / 2 h

3: 1.) t-BuLi / 1.) THF, -90 deg C, 30 min; 2.) THF, -78 deg C to 0 deg C, 4 h

4: 92 percent / MnO₂ / CH₂Cl₂ / 4 h / Ambient temperature

5: 77 percent / CuI / PdCl₂(PPh₃)2 / dimethylformamide / 2 h / 120 °C

6: 92 percent / KOH / ethanol; tetrahydrofuran / 2 h / Heating

7: 68 percent / 5M HCl / ethanol / 3 h / Heating

With hydrogenchloride; manganese(IV) oxide; potassium hydroxide; copper(l) iodide; iodine; tert.-butyl lithium; sodium hydride; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(96)01148-3