Dimethyl-thiocarbamic acid O-((2R,6R,11R)-6,11-dimethyl-3-phenethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-yl) ester

Base Information

Chemical Name:Dimethyl-thiocarbamic acid O-((2R,6R,11R)-6,11-dimethyl-3-phenethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-yl) ester
CAS No.:97948-95-3
Molecular Formula:C₂₅H₃₂N₂OS
Molecular Weight:408.608
Hs Code.:

Synonyms:Dimethyl-thiocarbamic acid O-((2R,6R,11R)-6,11-dimethyl-3-phenethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-yl) ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Dimethyl-thiocarbamic acid O-((2R,6R,11R)-6,11-dimethyl-3-phenethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-yl) ester

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Technology Process of Dimethyl-thiocarbamic acid O-((2R,6R,11R)-6,11-dimethyl-3-phenethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-yl) ester

There total 1 articles about Dimethyl-thiocarbamic acid O-((2R,6R,11R)-6,11-dimethyl-3-phenethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-yl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56942-74-6
(+/-)-phenazocine

: 16420-13-6
N,N-Dimethylthiocarbamoyl chloride

: 97948-95-3
Dimethyl-thiocarbamic acid O-((2R,6R,11R)-6,11-dimethyl-3-phenethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-yl) ester

Guidance literature:: With sodium hydride; Multistep reaction; 1.) DMF, RT, 1 h, 2.) DMF, 80 deg C, 1 h;
DOI:10.1021/jm00149a020

Reference yield: 74.0%

: 97948-95-3
Dimethyl-thiocarbamic acid O-((2R,6R,11R)-6,11-dimethyl-3-phenethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-yl) ester

: 97949-58-1
Dimethyl-thiocarbamic acid S-((2R,6R,11R)-3-benzyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-yl) ester

Guidance literature:: at 315 ℃; for 0.0666667h;
DOI:10.1021/jm00149a020

Reference yield:

: 97948-95-3
Dimethyl-thiocarbamic acid O-((2R,6R,11R)-6,11-dimethyl-3-phenethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-yl) ester

: 97949-06-9
Thiobenzoic acid S-((2R,6R,11R)-3-benzyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-yl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / 0.07 h / 315 °C

2: 1.) LiAlH₄ / 1.) THF, ether, 2 h, 2.) THF, ether, 0.5 h

With lithium aluminium tetrahydride;
DOI:10.1021/jm00149a020