17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14-(4'-carboxymethyI-phenethylamido)-morphinan-6-one

Base Information

Chemical Name:17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14-(4'-carboxymethyI-phenethylamido)-morphinan-6-one
CAS No.:1192542-79-2
Molecular Formula:C₃₁H₃₄N₂O₆
Molecular Weight:530.621
Hs Code.:

Synonyms:17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14-(4'-carboxymethyI-phenethylamido)-morphinan-6-one

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Chemical Property of 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14-(4'-carboxymethyI-phenethylamido)-morphinan-6-one

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Technology Process of 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14-(4'-carboxymethyI-phenethylamido)-morphinan-6-one

There total 4 articles about 17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14-(4'-carboxymethyI-phenethylamido)-morphinan-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1192542-78-1
17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14-(4'-carboxymethyI-phenethylamido)-morphinan-6-one

: 1192542-79-2
17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14-(4'-carboxymethyI-phenethylamido)-morphinan-6-one

Guidance literature:: 17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-14-(4'-carboxymethyI-phenethylamido)-morphinan-6-one; With boron tribromide; In dichloromethane; at -20 ℃;

With methanol; In dichloromethane; at -20 ℃;

Reference yield:

: C₃₀H₃₂N₂O₆

: 1192542-79-2
17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14-(4'-carboxymethyI-phenethylamido)-morphinan-6-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 1551.49 Torr

2.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 21 h / 20 °C

3.1: boron tribromide / dichloromethane / -20 °C

3.2: -20 °C

With hydrogen; boron tribromide; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In methanol; dichloromethane;

Reference yield:

: 5083-80-7
N-(cyclopropylmethyl)northebaine

: 1192542-79-2
17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-14-(4'-carboxymethyI-phenethylamido)-morphinan-6-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium periodate; sodium acetate / water; ethyl acetate / 0 °C

1.2: 1 h / 0 °C

1.3: pH > 7

2.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 1551.49 Torr

3.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 21 h / 20 °C

4.1: boron tribromide / dichloromethane / -20 °C

4.2: -20 °C

With sodium periodate; hydrogen; sodium acetate; boron tribromide; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In methanol; dichloromethane; water; ethyl acetate;