3-Benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1-[[2'-[(t-butoxycarbonylamino)methyl][1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3(R)-yl]-butanamide

Base Information

Chemical Name:3-Benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1-[[2'-[(t-butoxycarbonylamino)methyl][1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3(R)-yl]-butanamide
CAS No.:162356-94-7
Molecular Formula:C₄₂H₄₈N₄O₆
Molecular Weight:704.866
Hs Code.:

3-Benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1-[[2'-[(t-butoxycarbonylamino)methyl][1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3(R)-yl]-butanamide

Synonyms:3-Benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1-[[2'-[(t-butoxycarbonylamino)methyl][1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3(R)-yl]-butanamide

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Chemical Property of 3-Benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1-[[2'-[(t-butoxycarbonylamino)methyl][1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3(R)-yl]-butanamide

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Technology Process of 3-Benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1-[[2'-[(t-butoxycarbonylamino)methyl][1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3(R)-yl]-butanamide

There total 13 articles about 3-Benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1-[[2'-[(t-butoxycarbonylamino)methyl][1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3(R)-yl]-butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 145554-02-5
3-benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl]-butanamide

: 162356-93-6
4-Hydroxymethyl-2'(t-butoxycarbonylaminomethyl)-1,1'-biphenyl methanesulfonate ester

: 162356-94-7
3-Benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1-[[2'-[(t-butoxycarbonylamino)methyl][1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3(R)-yl]-butanamide

Guidance literature:: In N-methyl-acetamide; water; ethyl acetate;

Reference yield:

: 597-43-3
2,2-dimethylsuccinic acid

: 162356-94-7
3-Benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1-[[2'-[(t-butoxycarbonylamino)methyl][1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3(R)-yl]-butanamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) conc. H₂SO₄, 2.) Et₃N, diphenylphosphoryl azide

2: 99 percent / 2N aq. NaOH / methanol / 16 h / Ambient temperature

3: 94 percent / Et₃N, benzotriazol-1-yloxytripyrrolidinophosphonium hexafluorophosphate / CH₂Cl₂ / 2 h / Ambient temperature

4: 1.) NaH / 1.) DMF, 15 min, 2.) DMF, 0 deg C, 15 min

With sodium hydroxide; sulfuric acid; diphenylphosphoranyl azide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium hydride; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jm970816j

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 162356-94-7
3-Benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1-[[2'-[(t-butoxycarbonylamino)methyl][1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3(R)-yl]-butanamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Et₃N / 1.) methylene chloride, 0 deg C, 5 min, 2.) methylene chloride, 2 h

2: 100 percent / 5N aq. NaOH, Pd(PPh₃)4 / benzene; propan-2-ol / 2 h / Heating

3: 92 percent / Bu₄NF / tetrahydrofuran / 2 h / Ambient temperature

4: 97 percent / Et₃N / CH₂Cl₂ / 2 h / 0 °C

5: 1.) NaH / 1.) DMF, 15 min, 2.) DMF, 0 deg C, 15 min

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; isopropyl alcohol; benzene;
DOI:10.1021/jm970816j