(R,R)-N-[4-bromo-3-(4-ethoxyphenyl)isothiazol-5-yl]-2-methylcyclopropanecarboxamide

Base Information

Chemical Name:(R,R)-N-[4-bromo-3-(4-ethoxyphenyl)isothiazol-5-yl]-2-methylcyclopropanecarboxamide
CAS No.:1050393-15-1
Molecular Formula:C₁₆H₁₇BrN₂O₂S
Molecular Weight:381.293
Hs Code.:

Synonyms:(R,R)-N-[4-bromo-3-(4-ethoxyphenyl)isothiazol-5-yl]-2-methylcyclopropanecarboxamide

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Chemical Property of (R,R)-N-[4-bromo-3-(4-ethoxyphenyl)isothiazol-5-yl]-2-methylcyclopropanecarboxamide

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Technology Process of (R,R)-N-[4-bromo-3-(4-ethoxyphenyl)isothiazol-5-yl]-2-methylcyclopropanecarboxamide

There total 6 articles about (R,R)-N-[4-bromo-3-(4-ethoxyphenyl)isothiazol-5-yl]-2-methylcyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.5%

: 1050393-12-8
(1R,2R)-2-methyl-cyclopropanecarboxylic acid (3,4-dibromo-isothiazol-5-yl)-amide

: 22237-13-4
(4-ethoxyphenyl)boronic acid

: 1050393-15-1
(R,R)-N-[4-bromo-3-(4-ethoxyphenyl)isothiazol-5-yl]-2-methylcyclopropanecarboxamide

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; toluene; at 60 ℃;

Reference yield:

: 10487-86-2
(1R,2R)-2-methylcyclopropanecarboxylic acid

: 1050393-15-1
(R,R)-N-[4-bromo-3-(4-ethoxyphenyl)isothiazol-5-yl]-2-methylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 - 3 h / 0 - 40 °C / Heating / reflux

2: triethylamine / tetrahydrofuran; dichloromethane / 16 h / 0 - 20 °C

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide; toluene / 60 °C

With oxalyl dichloride; sodium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1050392-11-4
(1R,2R)-ethyl 2-methylcyclopropanecarboxylate

: 1050393-15-1
(R,R)-N-[4-bromo-3-(4-ethoxyphenyl)isothiazol-5-yl]-2-methylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide; water / 2-methyltetrahydrofuran; hexanes / 5 h / Heating / reflux

2: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 - 3 h / 0 - 40 °C / Heating / reflux

3: triethylamine / tetrahydrofuran; dichloromethane / 16 h / 0 - 20 °C

4: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide; toluene / 60 °C

With sodium hydroxide; oxalyl dichloride; water; sodium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,N-dimethyl-formamide; In tetrahydrofuran; 2-methyltetrahydrofuran; hexanes; dichloromethane; water; N,N-dimethyl-formamide; toluene;