4-{(S)-2-[(S)-2-(methoxycarbonylamino)-3-phenylpropanamido]-2-[2-(thiophen-2-yl)thiazol-4-yl]ethyl}phenylsulfamic acid

Base Information

• Chemical Name: 4-{(S)-2-[(S)-2-(methoxycarbonylamino)-3-phenylpropanamido]-2-[2-(thiophen-2-yl)thiazol-4-yl]ethyl}phenylsulfamic acid
• CAS No.: 1008510-37-9
• Molecular Formula: C₂₆H₂₆N₄O₆S₃
• Molecular Weight: 586.714

Synonyms:4-{(S)-2-[(S)-2-(methoxycarbonylamino)-3-phenylpropanamido]-2-[2-(thiophen-2-yl)thiazol-4-yl]ethyl}phenylsulfamic acid

Chemical Property of 4-{(S)-2-[(S)-2-(methoxycarbonylamino)-3-phenylpropanamido]-2-[2-(thiophen-2-yl)thiazol-4-yl]ethyl}phenylsulfamic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Razuprotafib 99.18% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Razuprotafib is a known VE-?PTP inhibitor that can effectively interact with the active site of VE-?PTP to inhibit the activity of VE-?PTP.

Technology Process of 4-{(S)-2-[(S)-2-(methoxycarbonylamino)-3-phenylpropanamido]-2-[2-(thiophen-2-yl)thiazol-4-yl]ethyl}phenylsulfamic acid

There total 7 articles about 4-{(S)-2-[(S)-2-(methoxycarbonylamino)-3-phenylpropanamido]-2-[2-(thiophen-2-yl)thiazol-4-yl]ethyl}phenylsulfamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.8%

sodium (4-{(S)-2-[(S)-2-(methoxycarbonylamino)-3-phenylpropanamido]-2-(2-(thiophen-2-yl)thiazol-4-yl)ethyl}phenyl)sulfamate → 4-{(S)-2-[(S)-2-(methoxycarbonylamino)-3-phenylpropanamido]-2-[2-(thiophen-2-yl)thiazol-4-yl]ethyl}phenylsulfamic acid (1008510-37-9)

Guidance literature:

With phosphoric acid; In water; acetone; at 20 ℃;

Reference yield:

(S)-2-(4-nitrophenyl)-1-(2-(thiophen-2-yl)thiazol-4-yl)ethanamine → 4-{(S)-2-[(S)-2-(methoxycarbonylamino)-3-phenylpropanamido]-2-[2-(thiophen-2-yl)thiazol-4-yl]ethyl}phenylsulfamic acid (1008510-37-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; 4-methyl-morpholine / tetrahydrofuran / 19 - 40 °C

2.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 24 h / 1551.49 - 2327.23 Torr / Inert atmosphere

2.2: 19 - 25 °C / Inert atmosphere

3.1: triethylamine / tetrahydrofuran / 19 - 40 °C / Inert atmosphere

4.1: sodium methylate / methanol / 19 - 25 °C

5.1: phosphoric acid / water; acetone / 20 °C

With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; phosphoric acid; palladium 10% on activated carbon; hydrogen; sodium methylate; triethylamine; In tetrahydrofuran; methanol; water; acetone;

Reference yield:

N-methoxycarbonyl-L-phenylalanine (41844-91-1) → 4-{(S)-2-[(S)-2-(methoxycarbonylamino)-3-phenylpropanamido]-2-[2-(thiophen-2-yl)thiazol-4-yl]ethyl}phenylsulfamic acid (1008510-37-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; 4-methyl-morpholine / tetrahydrofuran / 19 - 40 °C

2.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 24 h / 1551.49 - 2327.23 Torr / Inert atmosphere

2.2: 19 - 25 °C / Inert atmosphere

3.1: triethylamine / tetrahydrofuran / 19 - 40 °C / Inert atmosphere

4.1: sodium methylate / methanol / 19 - 25 °C

5.1: phosphoric acid / water; acetone / 20 °C

With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; phosphoric acid; palladium 10% on activated carbon; hydrogen; sodium methylate; triethylamine; In tetrahydrofuran; methanol; water; acetone;

upstream raw materials:

N-methoxycarbonyl-L-phenylalanine

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