2-{[(3R)-3-aminopiperidin-1-yl]methyl}benzonitrile

Base Information

Chemical Name:2-{[(3R)-3-aminopiperidin-1-yl]methyl}benzonitrile
CAS No.:1353254-17-7
Molecular Formula:C₁₃H₁₇N₃
Molecular Weight:215.298
Hs Code.:

Synonyms:2-{[(3R)-3-aminopiperidin-1-yl]methyl}benzonitrile

Suppliers and Price of 2-{[(3R)-3-aminopiperidin-1-yl]methyl}benzonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N1-(2-Cyanobenzyl)-3-aminopiperidine
500mg
$ 1540.00

Total 3 raw suppliers

Chemical Property of 2-{[(3R)-3-aminopiperidin-1-yl]methyl}benzonitrile

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

N1-(2-Cyanobenzyl)-3-aminopiperidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses N1-(2-Cyanobenzyl)-3-aminopiperidine is an impurity of alogliptin (A575425), which is an oral antihyperglycemic agent that is a selective inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4).Antidiabetic agent.

Technology Process of 2-{[(3R)-3-aminopiperidin-1-yl]methyl}benzonitrile

There total 3 articles about 2-{[(3R)-3-aminopiperidin-1-yl]methyl}benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1353254-15-5
tert-butyl [(3R)-1-(2-cyanobenzyl)piperidin-3-yl]carbamate

: 1353254-17-7
2-{[(3R)-3-aminopiperidin-1-yl]methyl}benzonitrile

Guidance literature:: tert-butyl [(3R)-1-(2-cyanobenzyl)piperidin-3-yl]carbamate; With trifluoroacetic acid; at 20 ℃; for 0.5h;

With sodium hydrogencarbonate; In ethyl acetate;

Reference yield:

: 22115-41-9
2-(bromomethyl)benzonitrile

: 1353254-17-7
2-{[(3R)-3-aminopiperidin-1-yl]methyl}benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / 2.5 h / 20 °C / Sealed vial

2: trifluoroacetic acid / 0.5 h / 20 °C

With potassium carbonate; trifluoroacetic acid;

Reference yield:

: 309956-78-3,172603-05-3
(R)-piperidin-3-ylcarbamic acid tert-butyl ester

: 1353254-17-7
2-{[(3R)-3-aminopiperidin-1-yl]methyl}benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / 2.5 h / 20 °C / Sealed vial

2: trifluoroacetic acid / 0.5 h / 20 °C

With potassium carbonate; trifluoroacetic acid;