N-[(4-chlorophenyl)sulfonyl]-3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-propanamide

Base Information

Chemical Name:N-[(4-chlorophenyl)sulfonyl]-3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-propanamide
CAS No.:926298-72-8
Molecular Formula:C₂₄H₂₁Cl₂F₃N₂O₆S
Molecular Weight:593.408
Hs Code.:

Synonyms:N-[(4-chlorophenyl)sulfonyl]-3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-propanamide

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Chemical Property of N-[(4-chlorophenyl)sulfonyl]-3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-propanamide

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Technology Process of N-[(4-chlorophenyl)sulfonyl]-3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-propanamide

There total 8 articles about N-[(4-chlorophenyl)sulfonyl]-3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-64-6
4-Chlorobenzenesulfonamide

: 3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]propanoic acid chloride

: 926298-72-8
N-[(4-chlorophenyl)sulfonyl]-3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-propanamide

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2012.03.036

Reference yield:

: 888740-08-7
ethyl 3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(methoxymethoxy)phenyl]propanoate

: 926298-72-8
N-[(4-chlorophenyl)sulfonyl]-3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-propanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; water / tetrahydrofuran / 0.75 h / 50 °C

2.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 0.08 h / 50 °C

3.1: sodium hydroxide / tetrahydrofuran; ethanol; water / 0.5 h / 50 °C

3.2: 20 °C

4.1: thionyl chloride; N,N-dimethyl-formamide / tetrahydrofuran / 2 h / 0 °C

5.1: dmap; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 20 °C

With hydrogenchloride; dmap; thionyl chloride; tributylphosphine; water; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; ethanol; water; 2.1: Mitsunobu reaction;
DOI:10.1016/j.bmc.2012.03.036

Reference yield:

: 3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]propanoic acid

: 926298-72-8
N-[(4-chlorophenyl)sulfonyl]-3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride; N,N-dimethyl-formamide / tetrahydrofuran / 2 h / 0 °C

2: dmap; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 20 °C

With dmap; thionyl chloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran;
DOI:10.1016/j.bmc.2012.03.036