1-(3-bromo-5-fluoro-2-methoxy-4-methylphenyl)ethanamine trifluoroacetate

Base Information

Chemical Name:1-(3-bromo-5-fluoro-2-methoxy-4-methylphenyl)ethanamine trifluoroacetate
CAS No.:1382996-52-2
Molecular Formula:C₂HF₃O₂*C₁₀H₁₃BrFNO
Molecular Weight:376.146
Hs Code.:

Synonyms:1-(3-bromo-5-fluoro-2-methoxy-4-methylphenyl)ethanamine trifluoroacetate

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Chemical Property of 1-(3-bromo-5-fluoro-2-methoxy-4-methylphenyl)ethanamine trifluoroacetate

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Technology Process of 1-(3-bromo-5-fluoro-2-methoxy-4-methylphenyl)ethanamine trifluoroacetate

There total 5 articles about 1-(3-bromo-5-fluoro-2-methoxy-4-methylphenyl)ethanamine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1382996-50-0
1-(3-bromo-5-fluoro-2-methoxy-4-methylphenyl)ethanone

: 76-05-1
trifluoroacetic acid

: 1382996-52-2
1-(3-bromo-5-fluoro-2-methoxy-4-methylphenyl)ethanamine trifluoroacetate

Guidance literature:: 1-(3-bromo-5-fluoro-2-methoxy-4-methylphenyl)ethanone; With methanol; ammonium acetate; sodium cyanoborohydride; In acetonitrile; at 65 ℃; for 3h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 452-70-0
4-fluoro-3-methylphenol

: 1382996-52-2
1-(3-bromo-5-fluoro-2-methoxy-4-methylphenyl)ethanamine trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 0 °C

2.1: boron trifluoride diacetate / 14 h / 155 °C

2.2: 0 °C

3.1: N-Bromosuccinimide / ethyl acetate / 18 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

5.1: methanol; ammonium acetate; sodium cyanoborohydride / acetonitrile / 3 h / 65 °C

With methanol; N-Bromosuccinimide; ammonium acetate; boron trifluoride diacetate; sodium cyanoborohydride; potassium carbonate; triethylamine; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1382996-49-7
1-(3-bromo-5-fluoro-2-hydroxy-4-methylphenyl)ethanone

: 1382996-52-2
1-(3-bromo-5-fluoro-2-methoxy-4-methylphenyl)ethanamine trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

2: methanol; ammonium acetate; sodium cyanoborohydride / acetonitrile / 3 h / 65 °C

With methanol; ammonium acetate; sodium cyanoborohydride; potassium carbonate; In N,N-dimethyl-formamide; acetonitrile;