ethyl 3,3-bis(4-fluorophenyl)-3-hydroxy-2-(1-methylethyl)-propionate

Base Information

• Chemical Name: ethyl 3,3-bis(4-fluorophenyl)-3-hydroxy-2-(1-methylethyl)-propionate
• CAS No.: 118559-07-2
• Molecular Formula: C₂₀H₂₂F₂O₃
• Molecular Weight: 348.39
• Mol file: 118559-07-2.mol

Synonyms:ethyl 3,3-bis(4-fluorophenyl)-3-hydroxy-2-(1-methylethyl)-propionate

Chemical Property of ethyl 3,3-bis(4-fluorophenyl)-3-hydroxy-2-(1-methylethyl)-propionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3,3-bis(4-fluorophenyl)-3-hydroxy-2-(1-methylethyl)-propionate

There total 2 articles about ethyl 3,3-bis(4-fluorophenyl)-3-hydroxy-2-(1-methylethyl)-propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

α-lithio ethyl isovalerate + 4,4'-Difluorobenzophenone (345-92-6) → ethyl 3,3-bis(4-fluorophenyl)-3-hydroxy-2-(1-methylethyl)-propionate (118559-07-2)

Guidance literature:

In tetrahydrofuran; 1.) 1.5 h, -78 deg C; 2.) 5 min, 0 deg C;

DOI:10.1016/S0040-4039(00)82484-3

Reference yield:

Ethyl isovalerate (108-64-5) + 4,4'-Difluorobenzophenone (345-92-6) → ethyl 3,3-bis(4-fluorophenyl)-3-hydroxy-2-(1-methylethyl)-propionate (118559-07-2)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, -78 deg C, 30 min, 2.) THF, a) -78 deg C, 2 h, b) 0 deg C, 10 min;

DOI:10.1246/bcsj.68.364

Reference yield: 100.0%

ethyl 3,3-bis(4-fluorophenyl)-3-hydroxy-2-(1-methylethyl)-propionate (118559-07-2) → ethyl 3,3-bis(4-fluorophenyl)-2-(1-methylethyl)propenoate (118559-08-3)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 1h; Heating;

DOI:10.1016/S0040-4039(00)82484-3

upstream raw materials:

4,4'-Difluorobenzophenone

Ethyl isovalerate

Downstream raw materials:

ethyl 3,3-bis(4-fluorophenyl)-2-(1-methylethyl)propenoate

2-di(4-fluorophenyl)methylene-3-methyl-1-butanol

2-di(4-fluorophenyl)methylidene-3-methylbutyl(diphenyl)phosphine oxide

Sodium; (E)-(3S,5R)-8-[bis-(4-fluoro-phenyl)-methylene]-3,5-dihydroxy-9-methyl-dec-6-enoate