(+)-(2R,3S)-[3-(3-methoxyphenyl)-2-methylpentyl]-dimethylamine Hydrochloride

Base Information

Chemical Name:(+)-(2R,3S)-[3-(3-methoxyphenyl)-2-methylpentyl]-dimethylamine Hydrochloride
CAS No.:1322723-45-4
Molecular Formula:C₁₅H₂₅NO*ClH
Molecular Weight:271.831
Hs Code.:

Synonyms:(+)-(2R,3S)-[3-(3-methoxyphenyl)-2-methylpentyl]-dimethylamine Hydrochloride

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Chemical Property of (+)-(2R,3S)-[3-(3-methoxyphenyl)-2-methylpentyl]-dimethylamine Hydrochloride

Chemical Property:

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Technology Process of (+)-(2R,3S)-[3-(3-methoxyphenyl)-2-methylpentyl]-dimethylamine Hydrochloride

There total 21 articles about (+)-(2R,3S)-[3-(3-methoxyphenyl)-2-methylpentyl]-dimethylamine Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-(3-methoxyphenyl)-N,N,2-trimethylpentan-1-amine

: 1322723-45-4
(+)-(2R,3S)-[3-(3-methoxyphenyl)-2-methylpentyl]-dimethylamine Hydrochloride

Guidance literature:: With hydrogenchloride; In di-isopropyl ether; at 25 - 30 ℃; for 2h;

Reference yield:

: 591-31-1
3-methoxy-benzaldehyde

: 1322723-45-4
(+)-(2R,3S)-[3-(3-methoxyphenyl)-2-methylpentyl]-dimethylamine Hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: tetrahydrofuran / -5 °C / Inert atmosphere

1.2: 0 °C

2.1: phosphorus tribromide / 0 - 25 °C

3.1: sodium hydride / dimethyl sulfoxide / 1 h / 25 °C

3.2: 5 h

4.1: sodium hydroxide; ethylene glycol / 4 h / 170 - 180 °C

4.2: pH 1

5.1: borane-dimethyl sulfide complex / tetrahydrofuran / 1 h / 50 - 55 °C / Inert atmosphere

5.2: 0 - 5 °C

6.1: triethylamine / dmap / dichloromethane / 6 h / 25 - 30 °C

7.1: sodium hydroxide / dimethyl sulfoxide / 0.5 h / 20 - 25 °C

7.2: 2 h / 40 - 45 °C

8.1: hydrogenchloride / di-isopropyl ether / 2 h / 25 - 30 °C

With hydrogenchloride; borane-dimethyl sulfide complex; phosphorus tribromide; sodium hydride; ethylene glycol; triethylamine; sodium hydroxide; dmap; In tetrahydrofuran; dichloromethane; di-isopropyl ether; dimethyl sulfoxide;

Reference yield:

: 52956-27-1
1-(3-methoxyphenyl)propanol

: 1322723-45-4
(+)-(2R,3S)-[3-(3-methoxyphenyl)-2-methylpentyl]-dimethylamine Hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: phosphorus tribromide / 0 - 25 °C

2.1: sodium hydride / dimethyl sulfoxide / 1 h / 25 °C

2.2: 5 h

3.1: sodium hydroxide; ethylene glycol / 4 h / 170 - 180 °C

3.2: pH 1

4.1: borane-dimethyl sulfide complex / tetrahydrofuran / 1 h / 50 - 55 °C / Inert atmosphere

4.2: 0 - 5 °C

5.1: triethylamine / dmap / dichloromethane / 6 h / 25 - 30 °C

6.1: sodium hydroxide / dimethyl sulfoxide / 0.5 h / 20 - 25 °C

6.2: 2 h / 40 - 45 °C

7.1: hydrogenchloride / di-isopropyl ether / 2 h / 25 - 30 °C

With hydrogenchloride; borane-dimethyl sulfide complex; phosphorus tribromide; sodium hydride; ethylene glycol; triethylamine; sodium hydroxide; dmap; In tetrahydrofuran; dichloromethane; di-isopropyl ether; dimethyl sulfoxide;