N-[(benzyloxy)carbonyl]glycyl-2-amino-2-methylpropanoyl-L-prolyl-2-amino-2-methylpropanoic acid

Base Information

Chemical Name:N-[(benzyloxy)carbonyl]glycyl-2-amino-2-methylpropanoyl-L-prolyl-2-amino-2-methylpropanoic acid
CAS No.:847165-34-8
Molecular Formula:C₂₃H₃₂N₄O₇
Molecular Weight:476.53
Hs Code.:

Synonyms:N-[(benzyloxy)carbonyl]glycyl-2-amino-2-methylpropanoyl-L-prolyl-2-amino-2-methylpropanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[(benzyloxy)carbonyl]glycyl-2-amino-2-methylpropanoyl-L-prolyl-2-amino-2-methylpropanoic acid

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Technology Process of N-[(benzyloxy)carbonyl]glycyl-2-amino-2-methylpropanoyl-L-prolyl-2-amino-2-methylpropanoic acid

There total 5 articles about N-[(benzyloxy)carbonyl]glycyl-2-amino-2-methylpropanoyl-L-prolyl-2-amino-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 847165-33-7
N-[(benzyloxy)carbonyl]glycyl-2-amino-2-methylpropanoyl-L-prolyl-2-amino-N,2-dimethyl-N-phenylpropanamide

: 847165-34-8
N-[(benzyloxy)carbonyl]glycyl-2-amino-2-methylpropanoyl-L-prolyl-2-amino-2-methylpropanoic acid

Guidance literature:: With hydrogenchloride; In acetonitrile; at 20 ℃; for 24h;
DOI:10.1002/hlca.200490275

Reference yield:

: 2420-11-3
Z-Gly-Aib-OH

: 847165-34-8
N-[(benzyloxy)carbonyl]glycyl-2-amino-2-methylpropanoyl-L-prolyl-2-amino-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / PyAOP; N-ethyl-diisopropylamine / CH₂Cl₂; acetonitrile / 18 h / 20 °C

2: 66 percent / aq. HCl / acetonitrile / 24 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;
DOI:10.1002/hlca.200490275

Reference yield:

: 71989-31-6
Fmoc-Pro-OH

: 847165-34-8
N-[(benzyloxy)carbonyl]glycyl-2-amino-2-methylpropanoyl-L-prolyl-2-amino-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / tetrahydrofuran / 60 h / 20 °C

2: 86 percent / Et₂NH / CH₂Cl₂ / 3 h / 20 °C

3: 94 percent / PyAOP; N-ethyl-diisopropylamine / CH₂Cl₂; acetonitrile / 18 h / 20 °C

4: 66 percent / aq. HCl / acetonitrile / 24 h / 20 °C

With hydrogenchloride; diethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1002/hlca.200490275